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Discovery and characterization of small molecules that target the GTPase Ral

Author

Listed:
  • Chao Yan

    (University of Colorado)

  • Degang Liu

    (Indiana University School of Medicine)

  • Liwei Li

    (Indiana University School of Medicine)

  • Michael F. Wempe

    (University of Colorado)

  • Sunny Guin

    (University of Colorado)

  • May Khanna

    (Indiana University School of Medicine)

  • Jeremy Meier

    (Cardiovascular Research Center, University of Virginia)

  • Brenton Hoffman

    (Cardiovascular Research Center, University of Virginia)

  • Charles Owens

    (University of Colorado)

  • Christina L. Wysoczynski

    (University of Colorado)

  • Matthew D. Nitz

    (Immunology, and Cancer Biology, University of Virginia)

  • William E. Knabe

    (Indiana University School of Medicine)

  • Mansoor Ahmed

    (Yale University
    Yale University)

  • David L. Brautigan

    (Immunology, and Cancer Biology, University of Virginia)

  • Bryce M. Paschal

    (University of Virginia)

  • Martin A. Schwartz

    (Yale University
    Yale University)

  • David N. M. Jones

    (University of Colorado)

  • David Ross

    (University of Colorado)

  • Samy O. Meroueh

    (Indiana University School of Medicine
    Indiana University – Purdue University)

  • Dan Theodorescu

    (University of Colorado
    University of Colorado
    University of Colorado Comprehensive Cancer Center)

Abstract

Using a structure-based approach, small molecule inhibitors that selectively target the GTPase Ral are identified and characterized; these first-generation inhibitors will be valuable tools for elucidating the Ral signalling pathway and constitute a step towards developing Ral-specific agents for cancer therapy.

Suggested Citation

  • Chao Yan & Degang Liu & Liwei Li & Michael F. Wempe & Sunny Guin & May Khanna & Jeremy Meier & Brenton Hoffman & Charles Owens & Christina L. Wysoczynski & Matthew D. Nitz & William E. Knabe & Mansoor, 2014. "Discovery and characterization of small molecules that target the GTPase Ral," Nature, Nature, vol. 515(7527), pages 443-447, November.
    • Handle: RePEc:nat:nature:v:515:y:2014:i:7527:d:10.1038_nature13713
    DOI: 10.1038/nature13713
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    Cited by:

    1. Si Jing Chen & Kazuya Hashimoto & Kosuke Fujio & Karin Hayashi & Sudip Kumar Paul & Akinori Yuzuriha & Wei-Yin Qiu & Emiri Nakamura & Maria Alejandra Kanashiro & Mio Kabata & Sou Nakamura & Naoshi Sug, 2024. "A let-7 microRNA-RALB axis links the immune properties of iPSC-derived megakaryocytes with platelet producibility," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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