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Transcript-RNA-templated DNA recombination and repair

Author

Listed:
  • Havva Keskin

    (School of Biology, Georgia Institute of Technology)

  • Ying Shen

    (School of Biology, Georgia Institute of Technology
    Present address: Division of Computational Biomedicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA.)

  • Fei Huang

    (Drexel University College of Medicine)

  • Mikir Patel

    (Drexel University College of Medicine)

  • Taehwan Yang

    (School of Biology, Georgia Institute of Technology)

  • Katie Ashley

    (School of Biology, Georgia Institute of Technology)

  • Alexander V. Mazin

    (Drexel University College of Medicine)

  • Francesca Storici

    (School of Biology, Georgia Institute of Technology)

Abstract

Endogenous RNA transcripts are shown to mediate recombination with yeast chromosomal DNA; as the level of RNAs in the nucleus is quite high, these results may open up new understanding of the plasticity of repair and genome instability mechanisms.

Suggested Citation

  • Havva Keskin & Ying Shen & Fei Huang & Mikir Patel & Taehwan Yang & Katie Ashley & Alexander V. Mazin & Francesca Storici, 2014. "Transcript-RNA-templated DNA recombination and repair," Nature, Nature, vol. 515(7527), pages 436-439, November.
    • Handle: RePEc:nat:nature:v:515:y:2014:i:7527:d:10.1038_nature13682
    DOI: 10.1038/nature13682
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    Cited by:

    1. Dayana E. Salas-Leiva & Eelco C. Tromer & Bruce A. Curtis & Jon Jerlström-Hultqvist & Martin Kolisko & Zhenzhen Yi & Joan S. Salas-Leiva & Lucie Gallot-Lavallée & Shelby K. Williams & Geert J. P. L. K, 2021. "Genomic analysis finds no evidence of canonical eukaryotic DNA processing complexes in a free-living protist," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    2. Manisha Jalan & Aman Sharma & Xin Pei & Nils Weinhold & Erika S. Buechelmaier & Yingjie Zhu & Sana Ahmed-Seghir & Abhirami Ratnakumar & Melody Bona & Niamh McDermott & Joan Gomez-Aguilar & Kyrie S. An, 2024. "RAD52 resolves transcription-replication conflicts to mitigate R-loop induced genome instability," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Guangxue Liu & Jimin Li & Boxue He & Jiaqi Yan & Jingyu Zhao & Xuejie Wang & Xiaocong Zhao & Jingyan Xu & Yeyao Wu & Simin Zhang & Xiaoli Gan & Chun Zhou & Xiangpan Li & Xinghua Zhang & Xuefeng Chen, 2023. "Bre1/RNF20 promotes Rad51-mediated strand exchange and antagonizes the Srs2/FBH1 helicases," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. Haibo Yang & Emily M. Lachtara & Xiaojuan Ran & Jessica Hopkins & Parasvi S. Patel & Xueping Zhu & Yao Xiao & Laiyee Phoon & Boya Gao & Lee Zou & Michael S. Lawrence & Li Lan, 2023. "The RNA m5C modification in R-loops as an off switch of Alt-NHEJ," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    5. Youngkyu Jeon & Yilin Lu & Margherita Maria Ferrari & Tejasvi Channagiri & Penghao Xu & Chance Meers & Yiqi Zhang & Sathya Balachander & Vivian S. Park & Stefania Marsili & Zachary F. Pursell & Nataša, 2024. "RNA-mediated double-strand break repair by end-joining mechanisms," Nature Communications, Nature, vol. 15(1), pages 1-24, December.

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