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Structural basis for the assembly of the Sxl–Unr translation regulatory complex

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  • Janosch Hennig

    (Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, DE-85764, Germany
    Center for Integrated Protein Science Munich at Biomolecular NMR Spectroscopy, Technische Universität München, Lichtenbergstr. 4, DE-85747 Garching, Germany)

  • Cristina Militti

    (Centre for Genomic Regulation, Gene Regulation, Stem Cells and Cancer Programme, Dr Aiguader 88, 08003 Barcelona, Spain
    Universisty Pompeu Fabra, Dr Aiguader 88, 08003 Barcelona, Spain)

  • Grzegorz M. Popowicz

    (Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, DE-85764, Germany
    Center for Integrated Protein Science Munich at Biomolecular NMR Spectroscopy, Technische Universität München, Lichtenbergstr. 4, DE-85747 Garching, Germany)

  • Iren Wang

    (Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, DE-85764, Germany
    Center for Integrated Protein Science Munich at Biomolecular NMR Spectroscopy, Technische Universität München, Lichtenbergstr. 4, DE-85747 Garching, Germany)

  • Miriam Sonntag

    (Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, DE-85764, Germany
    Center for Integrated Protein Science Munich at Biomolecular NMR Spectroscopy, Technische Universität München, Lichtenbergstr. 4, DE-85747 Garching, Germany)

  • Arie Geerlof

    (Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, DE-85764, Germany)

  • Frank Gabel

    (Université Grenoble Alpes, Institut de Biologie Structurale, F-38044 Grenoble, France
    Centre National de la Recherche Scientifique, Institut de Biologie Structurale, F-38044 Grenoble, France
    Commissariat à l'Energie Atomique et aux Energies Alternatives, Institut de Biologie Structurale, F-38044 Grenoble, France
    Institut Laue–Langevin, F-38042 Grenoble, France)

  • Fátima Gebauer

    (Centre for Genomic Regulation, Gene Regulation, Stem Cells and Cancer Programme, Dr Aiguader 88, 08003 Barcelona, Spain
    Universisty Pompeu Fabra, Dr Aiguader 88, 08003 Barcelona, Spain)

  • Michael Sattler

    (Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, DE-85764, Germany
    Center for Integrated Protein Science Munich at Biomolecular NMR Spectroscopy, Technische Universität München, Lichtenbergstr. 4, DE-85747 Garching, Germany)

Abstract

The crystal structure of the RNA binding domains of Sxl and Unr with msl2 RNA shows that interwoven interactions establish cooperative assembly of the ternary complex, highlighting how binding of relatively general RNA binding domains to RNA can result in a unique and specific protein–RNA architecture.

Suggested Citation

  • Janosch Hennig & Cristina Militti & Grzegorz M. Popowicz & Iren Wang & Miriam Sonntag & Arie Geerlof & Frank Gabel & Fátima Gebauer & Michael Sattler, 2014. "Structural basis for the assembly of the Sxl–Unr translation regulatory complex," Nature, Nature, vol. 515(7526), pages 287-290, November.
    • Handle: RePEc:nat:nature:v:515:y:2014:i:7526:d:10.1038_nature13693
    DOI: 10.1038/nature13693
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    Cited by:

    1. Chen Qiu & Zihan Zhang & Robert N. Wine & Zachary T. Campbell & Jun Zhang & Traci M. Tanaka Hall, 2023. "Intra- and inter-molecular regulation by intrinsically-disordered regions governs PUF protein RNA binding," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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