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Luminal signalling links cell communication to tissue architecture during organogenesis

Author

Listed:
  • Sevi Durdu

    (European Molecular Biology Laboratory Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany)

  • Murat Iskar

    (European Molecular Biology Laboratory Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany)

  • Celine Revenu

    (European Molecular Biology Laboratory Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Present address: Institut Curie, 26 rue d’Ulm, 75248 Paris, France.)

  • Nicole Schieber

    (European Molecular Biology Laboratory Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany)

  • Andreas Kunze

    (European Molecular Biology Laboratory Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany)

  • Peer Bork

    (European Molecular Biology Laboratory Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany)

  • Yannick Schwab

    (European Molecular Biology Laboratory Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany)

  • Darren Gilmour

    (European Molecular Biology Laboratory Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany)

Abstract

Groups of cells within a migrating collective assemble shared luminal cavities that trap and concentrate the signalling molecule fibroblast growth factor, providing a self-organising mechanism to focus and coordinate cell communication within tissues.

Suggested Citation

  • Sevi Durdu & Murat Iskar & Celine Revenu & Nicole Schieber & Andreas Kunze & Peer Bork & Yannick Schwab & Darren Gilmour, 2014. "Luminal signalling links cell communication to tissue architecture during organogenesis," Nature, Nature, vol. 515(7525), pages 120-124, November.
    • Handle: RePEc:nat:nature:v:515:y:2014:i:7525:d:10.1038_nature13852
    DOI: 10.1038/nature13852
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