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Crystal structure of the RNA-guided immune surveillance Cascade complex in Escherichia coli

Author

Listed:
  • Hongtu Zhao

    (Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Gang Sheng

    (Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences)

  • Jiuyu Wang

    (Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences)

  • Min Wang

    (Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences)

  • Gabor Bunkoczi

    (Cambridge Institute for Medical Research, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK)

  • Weimin Gong

    (Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences)

  • Zhiyi Wei

    (South University of Science and Technology of China)

  • Yanli Wang

    (Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences)

Abstract

The CRISPR/Cas system is an RNA-guided bacterial protection system against foreign nucleic acids of bacterial and archaeal origin; here a high-resolution crystal structure of the CRIPSR RNA–Cas complex shows that the CRIPSR RNA plays an essential role not only in target recognition but also in complex assembly.

Suggested Citation

  • Hongtu Zhao & Gang Sheng & Jiuyu Wang & Min Wang & Gabor Bunkoczi & Weimin Gong & Zhiyi Wei & Yanli Wang, 2014. "Crystal structure of the RNA-guided immune surveillance Cascade complex in Escherichia coli," Nature, Nature, vol. 515(7525), pages 147-150, November.
    • Handle: RePEc:nat:nature:v:515:y:2014:i:7525:d:10.1038_nature13733
    DOI: 10.1038/nature13733
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    Cited by:

    1. Kazuto Yoshimi & Kohei Takeshita & Noriyuki Kodera & Satomi Shibumura & Yuko Yamauchi & Mine Omatsu & Kenichi Umeda & Yayoi Kunihiro & Masaki Yamamoto & Tomoji Mashimo, 2022. "Dynamic mechanisms of CRISPR interference by Escherichia coli CRISPR-Cas3," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Meiling Lu & Chenlin Yu & Yuwen Zhang & Wenjun Ju & Zhi Ye & Chenyang Hua & Jinze Mao & Chunyi Hu & Zhenhuang Yang & Yibei Xiao, 2024. "Structure and genome editing of type I-B CRISPR-Cas," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    3. Qun Zhou & Yatong Zhao & Changqiang Ke & Haojun Wang & Sheng Gao & Hui Li & Yan Zhang & Yang Ye & Yunzi Luo, 2024. "Repurposing endogenous type I-E CRISPR-Cas systems for natural product discovery in Streptomyces," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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