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Sensory-evoked LTP driven by dendritic plateau potentials in vivo

Author

Listed:
  • Frédéric Gambino

    (CMU, University of Geneva, 1 rue Michel Servet, 1211 Geneva, Switzerland
    Present address: Institute for Interdisciplinary Neuroscience (IINS), UMR 5297 CNRS and University of Bordeaux, 146 rue Léo-Saignat, 33077 Bordeaux, France.)

  • Stéphane Pagès

    (CMU, University of Geneva, 1 rue Michel Servet, 1211 Geneva, Switzerland)

  • Vassilis Kehayas

    (CMU, University of Geneva, 1 rue Michel Servet, 1211 Geneva, Switzerland
    Lemanic Neuroscience Doctoral School, 1 rue Michel Servet, 1211 Geneva, Switzerland)

  • Daniela Baptista

    (CMU, University of Geneva, 1 rue Michel Servet, 1211 Geneva, Switzerland)

  • Roberta Tatti

    (CMU, University of Geneva, 1 rue Michel Servet, 1211 Geneva, Switzerland
    Lemanic Neuroscience Doctoral School, 1 rue Michel Servet, 1211 Geneva, Switzerland)

  • Alan Carleton

    (CMU, University of Geneva, 1 rue Michel Servet, 1211 Geneva, Switzerland)

  • Anthony Holtmaat

    (CMU, University of Geneva, 1 rue Michel Servet, 1211 Geneva, Switzerland)

Abstract

Whole-cell recordings in mouse somatosensory cortex in vivo show that rhythmic sensory-whisker stimulation induces long-term synaptic potentiation (LTP) in layer 2/3 (L2/3) pyramidal cells, in the absence of somatic spikes, through long-lasting NMDAR-mediated depolarizations that are generated by synaptic networks originating from the posteromedial complex of the thalamus.

Suggested Citation

  • Frédéric Gambino & Stéphane Pagès & Vassilis Kehayas & Daniela Baptista & Roberta Tatti & Alan Carleton & Anthony Holtmaat, 2014. "Sensory-evoked LTP driven by dendritic plateau potentials in vivo," Nature, Nature, vol. 515(7525), pages 116-119, November.
    • Handle: RePEc:nat:nature:v:515:y:2014:i:7525:d:10.1038_nature13664
    DOI: 10.1038/nature13664
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