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Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer

Author

Listed:
  • Diletta Di Mitri

    (Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland, Bellinzona CH6500, Switzerland)

  • Alberto Toso

    (Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland, Bellinzona CH6500, Switzerland)

  • Jing Jing Chen

    (Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland, Bellinzona CH6500, Switzerland
    Faculty of Biology and Medicine, University of Lausanne UNIL, Lausanne CH1011, Switzerland)

  • Manuela Sarti

    (Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland, Bellinzona CH6500, Switzerland)

  • Sandra Pinton

    (Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland, Bellinzona CH6500, Switzerland)

  • Tanja Rezzonico Jost

    (Institute for Research in Biomedicine (IRB))

  • Rocco D’Antuono

    (Institute for Research in Biomedicine (IRB))

  • Erica Montani

    (Institute for Research in Biomedicine (IRB))

  • Ramon Garcia-Escudero

    (Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland, Bellinzona CH6500, Switzerland
    Molecular Oncology Unit, CIEMAT, 28040 Madrid, Spain)

  • Ilaria Guccini

    (Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland, Bellinzona CH6500, Switzerland)

  • Sabela Da Silva-Alvarez

    (Laboratory of Stem Cells in Cancer and Aging, (stemCHUS) Health Research Institute of Santiago de Compostela (IDIS), Clinical University Hospital (CHUS), E15706 Santiago de Compostela, Spain)

  • Manuel Collado

    (Laboratory of Stem Cells in Cancer and Aging, (stemCHUS) Health Research Institute of Santiago de Compostela (IDIS), Clinical University Hospital (CHUS), E15706 Santiago de Compostela, Spain)

  • Mario Eisenberger

    (Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University)

  • Zhe Zhang

    (Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University)

  • Carlo Catapano

    (Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland, Bellinzona CH6500, Switzerland)

  • Fabio Grassi

    (Institute for Research in Biomedicine (IRB)
    University of Milan, Milan I-20100, Italy)

  • Andrea Alimonti

    (Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland, Bellinzona CH6500, Switzerland
    Faculty of Biology and Medicine, University of Lausanne UNIL, Lausanne CH1011, Switzerland)

Abstract

Senescence in cancer can be antagonized by a subset of immune cells acting in a non-cell-autonomous manner.

Suggested Citation

  • Diletta Di Mitri & Alberto Toso & Jing Jing Chen & Manuela Sarti & Sandra Pinton & Tanja Rezzonico Jost & Rocco D’Antuono & Erica Montani & Ramon Garcia-Escudero & Ilaria Guccini & Sabela Da Silva-Alv, 2014. "Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer," Nature, Nature, vol. 515(7525), pages 134-137, November.
    • Handle: RePEc:nat:nature:v:515:y:2014:i:7525:d:10.1038_nature13638
    DOI: 10.1038/nature13638
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