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Rapid fucosylation of intestinal epithelium sustains host–commensal symbiosis in sickness

Author

Listed:
  • Joseph M. Pickard

    (The University of Chicago)

  • Corinne F. Maurice

    (FAS Center for Systems Biology, Harvard University)

  • Melissa A. Kinnebrew

    (Memorial Sloan-Kettering Cancer Center)

  • Michael C. Abt

    (Memorial Sloan-Kettering Cancer Center)

  • Dominik Schenten

    (The University of Arizona)

  • Tatyana V. Golovkina

    (The University of Chicago)

  • Said R. Bogatyrev

    (California Institute of Technology)

  • Rustem F. Ismagilov

    (California Institute of Technology)

  • Eric G. Pamer

    (Memorial Sloan-Kettering Cancer Center)

  • Peter J. Turnbaugh

    (FAS Center for Systems Biology, Harvard University)

  • Alexander V. Chervonsky

    (The University of Chicago)

Abstract

Systemic exposure to Toll-like receptor (TLR) ligands during sickness is shown to induce fucosylation of the small intestine in mice; some of the fucose is shed into the intestinal lumen, where it provides nourishment for the microbiota.

Suggested Citation

  • Joseph M. Pickard & Corinne F. Maurice & Melissa A. Kinnebrew & Michael C. Abt & Dominik Schenten & Tatyana V. Golovkina & Said R. Bogatyrev & Rustem F. Ismagilov & Eric G. Pamer & Peter J. Turnbaugh , 2014. "Rapid fucosylation of intestinal epithelium sustains host–commensal symbiosis in sickness," Nature, Nature, vol. 514(7524), pages 638-641, October.
    • Handle: RePEc:nat:nature:v:514:y:2014:i:7524:d:10.1038_nature13823
    DOI: 10.1038/nature13823
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    Cited by:

    1. Yolanda Y. Huang & Morgan N. Price & Allison Hung & Omree Gal-Oz & Surya Tripathi & Christopher W. Smith & Davian Ho & Héloïse Carion & Adam M. Deutschbauer & Adam P. Arkin, 2024. "Barcoded overexpression screens in gut Bacteroidales identify genes with roles in carbon utilization and stress resistance," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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