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Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C

Author

Listed:
  • Katharine L. Sackton

    (Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Nevena Dimova

    (Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Xing Zeng

    (Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Wei Tian

    (University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390, USA
    Present addresses: Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China (W.T.); Department of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA (K.L.P.); Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA (F.S.).)

  • Mengmeng Zhang

    (Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Timothy B. Sackton

    (Harvard University, 26 Oxford Street, Cambridge, Massachusetts 02138, USA)

  • Johnathan Meaders

    (Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Kathleen L. Pfaff

    (Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Present addresses: Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China (W.T.); Department of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA (K.L.P.); Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA (F.S.).)

  • Frederic Sigoillot

    (Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Present addresses: Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China (W.T.); Department of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA (K.L.P.); Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA (F.S.).)

  • Hongtao Yu

    (University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390, USA
    Howard Hughes Medical Institute, 4000 Jones Bridge Road)

  • Xuelian Luo

    (University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390, USA)

  • Randall W. King

    (Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA)

Abstract

Simultaneous disruption of two different protein–protein interactions within the (APC/C–Cdc20)–substrate complex can synergistically inhibit APC/C-dependent proteolysis and mitotic exit.

Suggested Citation

  • Katharine L. Sackton & Nevena Dimova & Xing Zeng & Wei Tian & Mengmeng Zhang & Timothy B. Sackton & Johnathan Meaders & Kathleen L. Pfaff & Frederic Sigoillot & Hongtao Yu & Xuelian Luo & Randall W. K, 2014. "Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C," Nature, Nature, vol. 514(7524), pages 646-649, October.
    • Handle: RePEc:nat:nature:v:514:y:2014:i:7524:d:10.1038_nature13660
    DOI: 10.1038/nature13660
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