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Conditional tolerance of temperate phages via transcription-dependent CRISPR-Cas targeting

Author

Listed:
  • Gregory W. Goldberg

    (Laboratory of Bacteriology, The Rockefeller University, New York, New York 10065, USA)

  • Wenyan Jiang

    (Laboratory of Bacteriology, The Rockefeller University, New York, New York 10065, USA)

  • David Bikard

    (Laboratory of Bacteriology, The Rockefeller University, New York, New York 10065, USA
    Present address: Synthetic Biology Group, Institut Pasteur, 28 Rue du Dr. Roux, 75015 Paris, France.)

  • Luciano A. Marraffini

    (Laboratory of Bacteriology, The Rockefeller University, New York, New York 10065, USA)

Abstract

The Staphylococcus epidermidis CRISPR-Cas system can prevent lytic infection but tolerate lysogenization by temperate phage through a transcription-dependent DNA targeting mechanism.

Suggested Citation

  • Gregory W. Goldberg & Wenyan Jiang & David Bikard & Luciano A. Marraffini, 2014. "Conditional tolerance of temperate phages via transcription-dependent CRISPR-Cas targeting," Nature, Nature, vol. 514(7524), pages 633-637, October.
  • Handle: RePEc:nat:nature:v:514:y:2014:i:7524:d:10.1038_nature13637
    DOI: 10.1038/nature13637
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    Cited by:

    1. Evan A. Schwartz & Tess M. McBride & Jack P. K. Bravo & Daniel Wrapp & Peter C. Fineran & Robert D. Fagerlund & David W. Taylor, 2022. "Structural rearrangements allow nucleic acid discrimination by type I-D Cascade," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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