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Tryptophan catabolism is unaffected in chronic granulomatous disease

Author

Listed:
  • Ghassan J. Maghzal

    (Victor Chang Cardiac Research Institute
    School of Medicine, University of New South Wales
    School of Medical Sciences and Bosch Institute, The University of Sydney)

  • Susann Winter

    (Karolinska Institutet, 171 77 Stockholm, Sweden)

  • Bettina Wurzer

    (School of Medical Sciences and Bosch Institute, The University of Sydney)

  • Beng H. Chong

    (Centre for Vascular Research, University of New South Wales)

  • Rikard Holmdahl

    (Karolinska Institutet, 171 77 Stockholm, Sweden)

  • Roland Stocker

    (Victor Chang Cardiac Research Institute
    School of Medicine, University of New South Wales
    School of Medical Sciences and Bosch Institute, The University of Sydney)

Abstract

Arising from L. Romani et al. Nature 451, 211–215 (2008); doi:10.1038/nature06471 Chronic granulomatous disease (CGD) is an inherited disorder of phagocyte function, caused by a genetic defect in NADPH oxidase (NOX2), leading to an impaired ability of leukocytes to produce superoxide ( )1; CGD subjects are susceptible to chronic infections and hyper-inflammation, although the mechanisms remain unclear. Romani et al.2 reported an aberrant inflammatory response to pulmonary aspergillosis as well as sterile Aspergillus fumigatus to be mediated by a defective tryptophan catabolism to kynurenine caused by lack of in CGD mice. Kynurenine is formed by indoleamine 2,3-dioxygenase-1 (IDO1) in a reaction originally reported to depend on (ref. 3). Here we show that NOX2 deficiency does not attenuate IDO1-mediated tryptophan catabolism in human phagocytes and CGD mice with granulomas arising from an inflammatory response to Aspergillus. There is a Reply to this Brief Communications Arising by Romani, L. & Puccetti, P. Nature 514, http://dx.doi.org/10.1038/nature13845 (2014).

Suggested Citation

  • Ghassan J. Maghzal & Susann Winter & Bettina Wurzer & Beng H. Chong & Rikard Holmdahl & Roland Stocker, 2014. "Tryptophan catabolism is unaffected in chronic granulomatous disease," Nature, Nature, vol. 514(7523), pages 16-17, October.
    • Handle: RePEc:nat:nature:v:514:y:2014:i:7523:d:10.1038_nature13844
    DOI: 10.1038/nature13844
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