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Dendritic cells control fibroblastic reticular network tension and lymph node expansion

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  • Sophie E. Acton

    (Immunobiology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
    University College London, Gower Street, London WC1E 6BT, UK)

  • Aaron J. Farrugia

    (Immunobiology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
    Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK)

  • Jillian L. Astarita

    (Dana-Farber Cancer Institute)

  • Diego Mourão-Sá

    (Immunobiology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
    Present address: Laboratory of Immune Cell Epigenetics and Signaling, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA.)

  • Robert P. Jenkins

    (Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK)

  • Emma Nye

    (Experimental Histopathology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK)

  • Steven Hooper

    (Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK)

  • Janneke van Blijswijk

    (Immunobiology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK)

  • Neil C. Rogers

    (Immunobiology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK)

  • Kathryn J. Snelgrove

    (Immunobiology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK)

  • Ian Rosewell

    (Transgenics Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Potters Bar, Hertfordshire EN6 3LD, UK)

  • Luis F. Moita

    (Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal
    Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal)

  • Gordon Stamp

    (Experimental Histopathology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK)

  • Shannon J. Turley

    (Genentech, One DNA Way, South San Francisco, California 94080, USA)

  • Erik Sahai

    (Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK)

  • Caetano Reis e Sousa

    (Immunobiology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK)

Abstract

During inflammation, the lymph node stromal compartment is shown to accommodate high numbers of infiltrating lymphocytes by relaxing the cytoskeleton of fibroblastic reticular cells, allowing the latter to stretch and the lymph node to expand.

Suggested Citation

  • Sophie E. Acton & Aaron J. Farrugia & Jillian L. Astarita & Diego Mourão-Sá & Robert P. Jenkins & Emma Nye & Steven Hooper & Janneke van Blijswijk & Neil C. Rogers & Kathryn J. Snelgrove & Ian Rosewel, 2014. "Dendritic cells control fibroblastic reticular network tension and lymph node expansion," Nature, Nature, vol. 514(7523), pages 498-502, October.
    • Handle: RePEc:nat:nature:v:514:y:2014:i:7523:d:10.1038_nature13814
    DOI: 10.1038/nature13814
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