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Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers

Author

Listed:
  • Simona Chera

    (Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva-4, Switzerland)

  • Delphine Baronnier

    (Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva-4, Switzerland)

  • Luiza Ghila

    (Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva-4, Switzerland)

  • Valentina Cigliola

    (Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva-4, Switzerland)

  • Jan N. Jensen

    (Novo Nordisk A/S, Niels Steensens Vej 6, DK-2820 Gentofte, Denmark)

  • Guoqiang Gu

    (Cell and Developmental Biology, Vanderbilt University Medical Center, 465 21st Av. South, Nashville, Tennessee 37232, USA)

  • Kenichiro Furuyama

    (Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva-4, Switzerland)

  • Fabrizio Thorel

    (Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva-4, Switzerland)

  • Fiona M. Gribble

    (Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 0XY, UK)

  • Frank Reimann

    (Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 0XY, UK)

  • Pedro L. Herrera

    (Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva-4, Switzerland)

Abstract

An investigation of the influence of age on the generation of insulin-producing cells after β-cell loss in mice reveals that, whereas α-cells can reprogram to produce insulin from puberty to adulthood, efficient reconstitution in the very young is through δ-cell reprogramming, leading to complete diabetes recovery.

Suggested Citation

  • Simona Chera & Delphine Baronnier & Luiza Ghila & Valentina Cigliola & Jan N. Jensen & Guoqiang Gu & Kenichiro Furuyama & Fabrizio Thorel & Fiona M. Gribble & Frank Reimann & Pedro L. Herrera, 2014. "Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers," Nature, Nature, vol. 514(7523), pages 503-507, October.
    • Handle: RePEc:nat:nature:v:514:y:2014:i:7523:d:10.1038_nature13633
    DOI: 10.1038/nature13633
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