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Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

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Listed:
  • Panagiotis Ntziachristos

    (NYU School of Medicine
    NYU Cancer Institute and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine)

  • Aristotelis Tsirigos

    (NYU School of Medicine
    Center for Health Informatics and Bioinformatics, NYU School of Medicine)

  • G. Grant Welstead

    (Whitehead Institute for Biomedical Research
    Massachusetts Institute of Technology
    Present address: Editas Medicine, Cambridge, Massachusetts 02142, USA.)

  • Thomas Trimarchi

    (NYU School of Medicine
    NYU Cancer Institute and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine)

  • Sofia Bakogianni

    (NYU School of Medicine
    NYU Cancer Institute and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine)

  • Luyao Xu

    (Institute for Cancer Genetics, Columbia University Medical Center)

  • Evangelia Loizou

    (NYU School of Medicine
    NYU Cancer Institute and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine)

  • Linda Holmfeldt

    (St. Jude Children’s Research Hospital)

  • Alexandros Strikoudis

    (NYU School of Medicine
    NYU Cancer Institute and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine)

  • Bryan King

    (NYU School of Medicine
    NYU Cancer Institute and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine)

  • Jasper Mullenders

    (NYU School of Medicine
    NYU Cancer Institute and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine)

  • Jared Becksfort

    (St. Jude Children’s Research Hospital)

  • Jelena Nedjic

    (NYU School of Medicine
    NYU Cancer Institute and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine)

  • Elisabeth Paietta

    (Montefiore Medical Center North, Bronx)

  • Martin S. Tallman

    (Memorial Sloan Kettering Cancer Center)

  • Jacob M. Rowe

    (Technion, Israel Institute of Technology
    Shaare Zedek Medical Center)

  • Giovanni Tonon

    (Functional Genomics of Cancer Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, 20132 Milan, Italy)

  • Takashi Satoh

    (Laboratory of Host Defense, WPI Immunology Frontier Research Center (WPI IFReC), Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan
    Research Institute for Microbial Diseases (RIMD), Osaka University, 3-1Yamada-oka, Suita, Osaka 565-0871, Japan)

  • Laurens Kruidenier

    (Epinova DPU, Immuno-Inflammation Therapy Area, GlaxoSmithKline R&D, Medicines Research Centre, GunnelsWood Road, Stevenage SG1 2NY, UK)

  • Rab Prinjha

    (Epinova DPU, Immuno-Inflammation Therapy Area, GlaxoSmithKline R&D, Medicines Research Centre, GunnelsWood Road, Stevenage SG1 2NY, UK)

  • Shizuo Akira

    (Laboratory of Host Defense, WPI Immunology Frontier Research Center (WPI IFReC), Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan
    Research Institute for Microbial Diseases (RIMD), Osaka University, 3-1Yamada-oka, Suita, Osaka 565-0871, Japan)

  • Pieter Van Vlierberghe

    (Institute for Cancer Genetics, Columbia University Medical Center
    Center for Medical Genetics, Ghent University Hospital, 9000 Ghent, Belgium)

  • Adolfo A. Ferrando

    (Institute for Cancer Genetics, Columbia University Medical Center
    Columbia University Medical Center
    Columbia University Medical Center)

  • Rudolf Jaenisch

    (Whitehead Institute for Biomedical Research
    Massachusetts Institute of Technology)

  • Charles G. Mullighan

    (St. Jude Children’s Research Hospital)

  • Iannis Aifantis

    (NYU School of Medicine
    NYU Cancer Institute and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine)

Abstract

T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a poor prognosis and no available targeted therapies; now two histone H3 lysine 27 demethylases, JMJD3 and UTX, are shown to have contrasting roles in human T-ALL cells and a mouse model of the disease, and a small molecule demethylase inhibitor is found to inhibit the growth of T-ALL cell lines, introducing a potential therapeutic avenue for acute leukaemia.

Suggested Citation

  • Panagiotis Ntziachristos & Aristotelis Tsirigos & G. Grant Welstead & Thomas Trimarchi & Sofia Bakogianni & Luyao Xu & Evangelia Loizou & Linda Holmfeldt & Alexandros Strikoudis & Bryan King & Jasper , 2014. "Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia," Nature, Nature, vol. 514(7523), pages 513-517, October.
    • Handle: RePEc:nat:nature:v:514:y:2014:i:7523:d:10.1038_nature13605
    DOI: 10.1038/nature13605
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    Cited by:

    1. Zoe Veneti & Virginia Fasoulaki & Nikolaos Kalavros & Ioannis S. Vlachos & Christos Delidakis & Aristides G. Eliopoulos, 2024. "Polycomb-mediated silencing of miR-8 is required for maintenance of intestinal stemness in Drosophila melanogaster," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Alexandra D’Oto & Jie Fang & Hongjian Jin & Beisi Xu & Shivendra Singh & Anoushka Mullasseril & Victoria Jones & Ahmed Abu-Zaid & Xinyu Buttlar & Bailey Cooke & Dongli Hu & Jason Shohet & Andrew J. Mu, 2021. "KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma," Nature Communications, Nature, vol. 12(1), pages 1-19, December.

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