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High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity

Author

Listed:
  • Manon D. Schulz

    (Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, 81675 Munich, Germany)

  • Çiğdem Atay

    (Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, 81675 Munich, Germany)

  • Jessica Heringer

    (Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, 81675 Munich, Germany)

  • Franziska K. Romrig

    (Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, 81675 Munich, Germany)

  • Sarah Schwitalla

    (Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, 81675 Munich, Germany)

  • Begüm Aydin

    (Bogazici University, 34342 Bebek, Istanbul, Turkey)

  • Paul K. Ziegler

    (Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, 60596 Frankfurt am Main, Germany
    German Cancer Consortium (DKTK), 69120 Heidelberg, Germany
    German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Julia Varga

    (Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, 60596 Frankfurt am Main, Germany
    German Cancer Consortium (DKTK), 69120 Heidelberg, Germany
    German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Wolfgang Reindl

    (Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany)

  • Claudia Pommerenke

    (Microarray and Deep-Sequencing Core Facility, University Medical Center Göttingen, 37077 Göttingen, Germany)

  • Gabriela Salinas-Riester

    (Microarray and Deep-Sequencing Core Facility, University Medical Center Göttingen, 37077 Göttingen, Germany)

  • Andreas Böck

    (Institute for Mathematical Statistics, Technical University Munich, 81675 Munich, Germany)

  • Carl Alpert

    (German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany
    Present address: Frutarom Savory Solutions, 49451 Holdorf, Germany.)

  • Michael Blaut

    (German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany)

  • Sara C. Polson

    (Center for Bioinformatics and Computational Biology, Delaware Biotechnology Institute, University of Delaware)

  • Lydia Brandl

    (Institute of Pathology, Ludwig Maximilians University, 80337 Munich, Germany)

  • Thomas Kirchner

    (German Cancer Consortium (DKTK), 69120 Heidelberg, Germany
    German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
    Institute of Pathology, Ludwig Maximilians University, 80337 Munich, Germany)

  • Florian R. Greten

    (Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, 60596 Frankfurt am Main, Germany
    German Cancer Consortium (DKTK), 69120 Heidelberg, Germany
    German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Shawn W. Polson

    (Center for Bioinformatics and Computational Biology, Delaware Biotechnology Institute, University of Delaware)

  • Melek C. Arkan

    (Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, 81675 Munich, Germany)

Abstract

A high-fat diet promotes intestinal tumorigenesis independently of obesity in a mouse model with oncogene activation, by changing the composition of the gut microbiota and altering immune regulation.

Suggested Citation

  • Manon D. Schulz & Çiğdem Atay & Jessica Heringer & Franziska K. Romrig & Sarah Schwitalla & Begüm Aydin & Paul K. Ziegler & Julia Varga & Wolfgang Reindl & Claudia Pommerenke & Gabriela Salinas-Rieste, 2014. "High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity," Nature, Nature, vol. 514(7523), pages 508-512, October.
    • Handle: RePEc:nat:nature:v:514:y:2014:i:7523:d:10.1038_nature13398
    DOI: 10.1038/nature13398
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