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Rb suppresses human cone-precursor-derived retinoblastoma tumours

Author

Listed:
  • Xiaoliang L. Xu

    (Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA)

  • Hardeep P. Singh

    (The Vision Center, Children’s Hospital Los Angeles, 4650 Sunset Boulevard, Los Angeles, California 90027, USA
    The Saban Research Institute, Children’s Hospital Los Angeles, 4650 Sunset Boulevard, Los Angeles, California 90027, USA)

  • Lu Wang

    (Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA)

  • Dong-Lai Qi

    (The Vision Center, Children’s Hospital Los Angeles, 4650 Sunset Boulevard, Los Angeles, California 90027, USA
    The Saban Research Institute, Children’s Hospital Los Angeles, 4650 Sunset Boulevard, Los Angeles, California 90027, USA)

  • Bradford K. Poulos

    (Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA)

  • David H. Abramson

    (Ophthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA)

  • Suresh C. Jhanwar

    (Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA)

  • David Cobrinik

    (The Vision Center, Children’s Hospital Los Angeles, 4650 Sunset Boulevard, Los Angeles, California 90027, USA
    The Saban Research Institute, Children’s Hospital Los Angeles, 4650 Sunset Boulevard, Los Angeles, California 90027, USA
    USC Eye Institute, Keck School of Medicine of the University of Southern California, 1450 San Pablo Street, Los Angeles, California 90033, USA
    Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, 1441 Eastlake Avenue, Los Angeles, California 90033, USA)

Abstract

The nature of the retinal cell-type-specific circuitry that predisposes to retinoblastoma is demonstrated, in which a program that is unique to post-mitotic human cone precursors sensitizes to the oncogenic effects of retinoblastoma (Rb) protein depletion; hence, the loss of Rb collaborates with the molecular framework of cone precursors to initiate tumorigenesis.

Suggested Citation

  • Xiaoliang L. Xu & Hardeep P. Singh & Lu Wang & Dong-Lai Qi & Bradford K. Poulos & David H. Abramson & Suresh C. Jhanwar & David Cobrinik, 2014. "Rb suppresses human cone-precursor-derived retinoblastoma tumours," Nature, Nature, vol. 514(7522), pages 385-388, October.
    • Handle: RePEc:nat:nature:v:514:y:2014:i:7522:d:10.1038_nature13813
    DOI: 10.1038/nature13813
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    Cited by:

    1. Irsan E Kooi & Berber M Mol & Maarten P G Massink & Marcus C de Jong & Pim de Graaf & Paul van der Valk & Hanne Meijers-Heijboer & Gertjan J L Kaspers & Annette C Moll & Hein te Riele & Jacqueline Clo, 2016. "A Meta-Analysis of Retinoblastoma Copy Numbers Refines the List of Possible Driver Genes Involved in Tumor Progression," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-20, April.

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