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Required enhancer–matrin-3 network interactions for a homeodomain transcription program

Author

Listed:
  • Dorota Skowronska-Krawczyk

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA)

  • Qi Ma

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA)

  • Michal Schwartz

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University)

  • Kathleen Scully

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA)

  • Wenbo Li

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA)

  • Zhijie Liu

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA)

  • Havilah Taylor

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA)

  • Jessica Tollkuhn

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA)

  • Kenneth A. Ohgi

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA)

  • Dimple Notani

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA)

  • Yoshinori Kohwi

    (Lawrence Berkeley National Laboratory)

  • Terumi Kohwi-Shigematsu

    (Lawrence Berkeley National Laboratory)

  • Michael G. Rosenfeld

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA)

Abstract

The POU homeodomain transcription factor Pit1 is required for pituitary development; here Pit1-occupied enhancers are shown to interact with the nuclear architecture components matrin-3 and Satb1, and this association is required for activation of Pit1-regulated enhancers and coding target genes.

Suggested Citation

  • Dorota Skowronska-Krawczyk & Qi Ma & Michal Schwartz & Kathleen Scully & Wenbo Li & Zhijie Liu & Havilah Taylor & Jessica Tollkuhn & Kenneth A. Ohgi & Dimple Notani & Yoshinori Kohwi & Terumi Kohwi-Sh, 2014. "Required enhancer–matrin-3 network interactions for a homeodomain transcription program," Nature, Nature, vol. 514(7521), pages 257-261, October.
    • Handle: RePEc:nat:nature:v:514:y:2014:i:7521:d:10.1038_nature13573
    DOI: 10.1038/nature13573
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    Cited by:

    1. Hye Ji Cha & Özgün Uyan & Yan Kai & Tianxin Liu & Qian Zhu & Zuzana Tothova & Giovanni A. Botten & Jian Xu & Guo-Cheng Yuan & Job Dekker & Stuart H. Orkin, 2021. "Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture," Nature Communications, Nature, vol. 12(1), pages 1-19, December.

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