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Protein competition switches the function of COP9 from self-renewal to differentiation

Author

Listed:
  • Lei Pan

    (Stowers Institute for Medical Research, 1000 East 50th Street
    Chinese Academy of Sciences Key Laboratory of Infection and Immunity, Institute of Biophysics, 15 Da Tun Road, Beijing 100101, China)

  • Su Wang

    (Stowers Institute for Medical Research, 1000 East 50th Street
    University of Kansas School of Medicine, 3901 Rainbow Boulevard, Kansas City, Kansas 66160, USA)

  • Tinglin Lu

    (Center for Life Sciences, School of Medicine, Tsinghua University)

  • Changjiang Weng

    (Stowers Institute for Medical Research, 1000 East 50th Street)

  • Xiaoqing Song

    (Stowers Institute for Medical Research, 1000 East 50th Street)

  • Joseph K. Park

    (University of Texas Southwestern Medical Center
    Howard Hughes Medical Institute)

  • Jin Sun

    (Center for Life Sciences, School of Medicine, Tsinghua University)

  • Zhi-Hao Yang

    (Center for Life Sciences, School of Medicine, Tsinghua University)

  • Junjing Yu

    (Stowers Institute for Medical Research, 1000 East 50th Street
    Chinese Academy of Sciences Key Laboratory of Infection and Immunity, Institute of Biophysics, 15 Da Tun Road, Beijing 100101, China)

  • Hong Tang

    (Chinese Academy of Sciences Key Laboratory of Infection and Immunity, Institute of Biophysics, 15 Da Tun Road, Beijing 100101, China)

  • Dennis M. McKearin

    (University of Texas Southwestern Medical Center
    Howard Hughes Medical Institute)

  • Daniel A. Chamovitz

    (Tel Aviv University, Tel Aviv 69978, Israel)

  • Jianquan Ni

    (Center for Life Sciences, School of Medicine, Tsinghua University)

  • Ting Xie

    (Stowers Institute for Medical Research, 1000 East 50th Street
    University of Kansas School of Medicine, 3901 Rainbow Boulevard, Kansas City, Kansas 66160, USA)

Abstract

Using biochemical and genetic approaches, a protein-competition-based mechanism that controls the balance between stem cell self-renewal and differentiation of germline stem cells in the Drosophila melanogaster ovary has been uncovered.

Suggested Citation

  • Lei Pan & Su Wang & Tinglin Lu & Changjiang Weng & Xiaoqing Song & Joseph K. Park & Jin Sun & Zhi-Hao Yang & Junjing Yu & Hong Tang & Dennis M. McKearin & Daniel A. Chamovitz & Jianquan Ni & Ting Xie, 2014. "Protein competition switches the function of COP9 from self-renewal to differentiation," Nature, Nature, vol. 514(7521), pages 233-236, October.
    • Handle: RePEc:nat:nature:v:514:y:2014:i:7521:d:10.1038_nature13562
    DOI: 10.1038/nature13562
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