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PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies

Author

Listed:
  • Thomas De Raedt

    (Brigham and Women’s Hospital
    Harvard Medical School
    Ludwig Center at Dana-Farber/Harvard Cancer Center)

  • Eline Beert

    (Catholic University Leuven, 3000 Leuven, Belgium
    Present address: Laboratory of Aquatic Biology, Interdisciplinary Research Facility Life Sciences, Katholieke Universiteit, Leuven Afdeling Kortrijk, 8500 Kortrijk, Belgium.)

  • Eric Pasmant

    (INSERM UMR_S745 et EA7331, Université Paris Descartes, Sorbonne Paris Cité, Faculté des Sciences Pharmaceutiques et Biologiques, 75006 Paris, France
    Service de Biochimie et Génétique Moléculaire, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, 75014 Paris, France)

  • Armelle Luscan

    (INSERM UMR_S745 et EA7331, Université Paris Descartes, Sorbonne Paris Cité, Faculté des Sciences Pharmaceutiques et Biologiques, 75006 Paris, France
    Service de Biochimie et Génétique Moléculaire, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, 75014 Paris, France)

  • Hilde Brems

    (Catholic University Leuven, 3000 Leuven, Belgium)

  • Nicolas Ortonne

    (INSERM UMR_S745 et EA7331, Université Paris Descartes, Sorbonne Paris Cité, Faculté des Sciences Pharmaceutiques et Biologiques, 75006 Paris, France
    Service de Biochimie et Génétique Moléculaire, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, 75014 Paris, France)

  • Kristian Helin

    (Biotech Research and Innovation Centre (BRIC), University of Copenhagen, 2200 Copenhagen, Denmark
    Center for Epigenetics, University of Copenhagen, 2200 Copenhagen, Denmark
    The Danish Stem Cell Center (Danstem), University of Copenhagen, 2200 Copenhagen, Denmark)

  • Jason L. Hornick

    (Brigham and Women’s Hospital)

  • Victor Mautner

    (University Medical Centre, Hamburg-Eppendorf, 20246 Hamburg, Germany)

  • Hildegard Kehrer-Sawatzki

    (Institute of Human Genetics, University of Ulm, 89081 Ulm, Germany)

  • Wade Clapp

    (Herman Wells Center for Pediatric Research, Indiana University School of Medicine)

  • James Bradner

    (Harvard Medical School
    Dana-Farber Cancer Institute)

  • Michel Vidaud

    (INSERM UMR_S745 et EA7331, Université Paris Descartes, Sorbonne Paris Cité, Faculté des Sciences Pharmaceutiques et Biologiques, 75006 Paris, France
    Service de Biochimie et Génétique Moléculaire, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, 75014 Paris, France)

  • Meena Upadhyaya

    (Institute of Medical Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK)

  • Eric Legius

    (Catholic University Leuven, 3000 Leuven, Belgium
    Center for Human Genetics, University Hospital Leuven, 3000 Leuven Belgium)

  • Karen Cichowski

    (Brigham and Women’s Hospital
    Harvard Medical School
    Ludwig Center at Dana-Farber/Harvard Cancer Center)

Abstract

SUZ12, a component of the PRC2 complex, can also function as a tumour suppressor in certain tumours of the nervous system and melanomas.

Suggested Citation

  • Thomas De Raedt & Eline Beert & Eric Pasmant & Armelle Luscan & Hilde Brems & Nicolas Ortonne & Kristian Helin & Jason L. Hornick & Victor Mautner & Hildegard Kehrer-Sawatzki & Wade Clapp & James Brad, 2014. "PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies," Nature, Nature, vol. 514(7521), pages 247-251, October.
    • Handle: RePEc:nat:nature:v:514:y:2014:i:7521:d:10.1038_nature13561
    DOI: 10.1038/nature13561
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    Cited by:

    1. Marta Martínez & Carlos O S Sorzano & Alberto Pascual-Montano & Jose M Carazo, 2017. "Gene signature associated with benign neurofibroma transformation to malignant peripheral nerve sheath tumors," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-27, May.

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