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Hemani et al. reply

Author

Listed:
  • Gibran Hemani

    (Queensland Brain Institute, University of Queensland
    University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital)

  • Konstantin Shakhbazov

    (Queensland Brain Institute, University of Queensland
    University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital)

  • Harm-Jan Westra

    (University Medical Center Groningen, University of Groningen)

  • Tonu Esko

    (Estonian Genome Center, University of Tartu
    Medical and Population Genetics, Broad Institute
    Children's Hospital)

  • Anjali K. Henders

    (Queensland Institute of Medical Research)

  • Allan F. McRae

    (Queensland Brain Institute, University of Queensland
    University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital)

  • Jian Yang

    (Queensland Brain Institute, University of Queensland)

  • Greg Gibson

    (School of Biology and Centre for Integrative Genomics, Georgia Institute of Technology)

  • Nicholas G. Martin

    (Queensland Institute of Medical Research)

  • Andres Metspalu

    (Estonian Genome Center, University of Tartu)

  • Lude Franke

    (University Medical Center Groningen, University of Groningen)

  • Grant W. Montgomery

    (Queensland Institute of Medical Research)

  • Peter M. Visscher

    (Queensland Brain Institute, University of Queensland
    University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital)

  • Joseph E. Powell

    (Queensland Brain Institute, University of Queensland
    University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital)

Abstract

Replying to A. R. Wood et al. Nature 514, 10.1038/nature13691 (2014). We thank Wood et al. 1 for their interesting observations and although their proposed mechanism does not explain all our reported results, we acknowledge that alternative mechanisms could be behind the observation of epistatic signals. Although we replicate our results in large, independent samples, 19/30 of our reported interactions (Table 1 in ref. 2), Wood et al.1 do not replicate in the InCHIANTI data set (n = 450) at a type-I error rate of 0.05/30 = 0.002, including none of our reported cis–trans interactions. Having insufficient data to replicate the discovery interactions makes it problematic to draw firm conclusions on the reported cis–trans effects.

Suggested Citation

  • Gibran Hemani & Konstantin Shakhbazov & Harm-Jan Westra & Tonu Esko & Anjali K. Henders & Allan F. McRae & Jian Yang & Greg Gibson & Nicholas G. Martin & Andres Metspalu & Lude Franke & Grant W. Montg, 2014. "Hemani et al. reply," Nature, Nature, vol. 514(7520), pages 5-6, October.
    • Handle: RePEc:nat:nature:v:514:y:2014:i:7520:d:10.1038_nature13692
    DOI: 10.1038/nature13692
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