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A long noncoding RNA protects the heart from pathological hypertrophy

Author

Listed:
  • Pei Han

    (Indiana University School of Medicine
    Cardiovascular Institute, Stanford University School of Medicine)

  • Wei Li

    (Indiana University School of Medicine
    Cardiovascular Institute, Stanford University School of Medicine)

  • Chiou-Hong Lin

    (Cardiovascular Institute, Stanford University School of Medicine)

  • Jin Yang

    (Indiana University School of Medicine)

  • Ching Shang

    (Cardiovascular Institute, Stanford University School of Medicine)

  • Sylvia T. Nurnberg

    (Cardiovascular Institute, Stanford University School of Medicine)

  • Kevin Kai Jin

    (Cardiovascular Institute, Stanford University School of Medicine)

  • Weihong Xu

    (Stanford Genome Technology Center, Stanford University School of Medicine)

  • Chieh-Yu Lin

    (Cardiovascular Institute, Stanford University School of Medicine)

  • Chien-Jung Lin

    (Cardiovascular Institute, Stanford University School of Medicine)

  • Yiqin Xiong

    (Cardiovascular Institute, Stanford University School of Medicine)

  • Huan-Chieh Chien

    (Cardiovascular Institute, Stanford University School of Medicine)

  • Bin Zhou

    (Pediatrics, and Medicine (Cardiology), Albert Einstein College of Medicine of Yeshiva University, 1301 Morris Park Avenue, Price Center 420)

  • Euan Ashley

    (Cardiovascular Institute, Stanford University School of Medicine)

  • Daniel Bernstein

    (Stanford University School of Medicine)

  • Peng-Sheng Chen

    (Indiana University School of Medicine)

  • Huei-Sheng Vincent Chen

    (Del E. Webb Neuroscience, Aging & Stem Cell Research Center, Sanford/Burnham Medical Research Institute)

  • Thomas Quertermous

    (Cardiovascular Institute, Stanford University School of Medicine)

  • Ching-Pin Chang

    (Indiana University School of Medicine
    Indiana University School of Medicine
    Indiana University School of Medicine)

Abstract

Here, a long noncoding RNA, termed Mhrt, is identified in the loci of myosin heavy chain (Myh) genes in mice and shown to be capable of suppressing cardiomyopathy in the animals, as well as being repressed in diseased human hearts.

Suggested Citation

  • Pei Han & Wei Li & Chiou-Hong Lin & Jin Yang & Ching Shang & Sylvia T. Nurnberg & Kevin Kai Jin & Weihong Xu & Chieh-Yu Lin & Chien-Jung Lin & Yiqin Xiong & Huan-Chieh Chien & Bin Zhou & Euan Ashley &, 2014. "A long noncoding RNA protects the heart from pathological hypertrophy," Nature, Nature, vol. 514(7520), pages 102-106, October.
    • Handle: RePEc:nat:nature:v:514:y:2014:i:7520:d:10.1038_nature13596
    DOI: 10.1038/nature13596
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    Cited by:

    1. Sandra Rogala & Tamer Ali & Maria-Theodora Melissari & Sandra Währisch & Peggy Schuster & Alexandre Sarre & Rebeca Cordellini Emídio & Thomas Boettger & Eva-Maria Rogg & Jaskiran Kaur & Jaya Krishnan , 2023. "The lncRNA Sweetheart regulates compensatory cardiac hypertrophy after myocardial injury in murine males," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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