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Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

Author

Listed:
  • John R. B. Perry

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
    University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
    King’s College London, London SE1 7EH, UK.)

  • Felix Day

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.)

  • Cathy E. Elks

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.)

  • Patrick Sulem

    (deCODE Genetics, Reykjavik IS-101, Iceland.)

  • Deborah J. Thompson

    (Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.)

  • Teresa Ferreira

    (Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.)

  • Chunyan He

    (Indiana University Richard M Fairbanks School of Public Health
    Indiana University Melvin and Bren Simon Cancer Center)

  • Daniel I. Chasman

    (Brigham and Women’s Hospital
    Harvard Medical School)

  • Tõnu Esko

    (Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
    Boston Children’s Hospital
    Broad Institute of the Massachusetts Institute of Technology and Harvard University
    Harvard Medical School)

  • Gudmar Thorleifsson

    (deCODE Genetics, Reykjavik IS-101, Iceland.)

  • Eva Albrecht

    (Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.)

  • Wei Q. Ang

    (School of Women’s and Infants’ Health, The University of Western Australia, WA-6009, Australia.)

  • Tanguy Corre

    (University of Lausanne, CH-1005 Lausanne, Switzerland.
    Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland.)

  • Diana L. Cousminer

    (Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI-00014, Finland.)

  • Bjarke Feenstra

    (Statens Serum Institut, DK-2300 Copenhagen, Denmark.)

  • Nora Franceschini

    (University of North Carolina)

  • Andrea Ganna

    (Karolinska Institutet, 17177 Stockholm, Sweden.)

  • Andrew D. Johnson

    (NHLBI’s and Boston University’s Framingham Heart Study)

  • Sanela Kjellqvist

    (Science for Life Laboratory, Karolinska Institutet, Stockholm, Box 1031, 17121 Solna, Sweden.)

  • Kathryn L. Lunetta

    (NHLBI’s and Boston University’s Framingham Heart Study
    Boston University School of Public Health)

  • George McMahon

    (MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK.
    School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.)

  • Ilja M. Nolte

    (University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.)

  • Lavinia Paternoster

    (MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK.)

  • Eleonora Porcu

    (Institute of Genetics and Biomedical Research, National Research Council, Cagliari, 09042 Sardinia, Italy.
    University of Sassari, 07100 Sassari, Italy.)

  • Albert V. Smith

    (Icelandic Heart Association, IS-201 Kopavogur, Iceland.
    University of Iceland, IS-101 Reykjavik, Iceland.)

  • Lisette Stolk

    (Erasmus MC, 3015 GE Rotterdam, the Netherlands.
    Netherlands Consortium on Health Aging and National Genomics Initiative, 2300 RC Leiden, the Netherlands.)

  • Alexander Teumer

    (Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany.)

  • Natalia Tšernikova

    (Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
    University of Tartu, 51010 Tartu, Estonia.)

  • Emmi Tikkanen

    (Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI-00014, Finland.
    Hjelt Institute, University of Helsinki, FI-00014, Finland.)

  • Sheila Ulivi

    (Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”, 34137 Trieste, Italy.)

  • Erin K. Wagner

    (Indiana University Richard M Fairbanks School of Public Health
    Indiana University Melvin and Bren Simon Cancer Center)

  • Najaf Amin

    (Erasmus MC, 3015 GE, Rotterdam, the Netherlands.)

  • Laura J. Bierut

    (Washington University)

  • Enda M. Byrne

    (The University of Queensland, Queensland Brain Institute, St Lucia, Queensland 4072, Australia.
    QIMR Berghofer Medical Research Institute)

  • Jouke-Jan Hottenga

    (VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.)

  • Daniel L. Koller

    (Indiana University School of Medicine)

  • Massimo Mangino

    (King’s College London, London SE1 7EH, UK.)

  • Tune H. Pers

    (Boston Children’s Hospital
    Broad Institute of the Massachusetts Institute of Technology and Harvard University
    Medical and Population Genetics, Broad Institute
    Center for Biological Sequence Analysis, Technical 142 University of Denmark, DK-2800 Lyngby, Denmark.)

  • Laura M. Yerges-Armstrong

    (Program in Personalized and Genomic Medicine, Diabetes and Nutrition, University of Maryland School of Medicine)

  • Jing Hua Zhao

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.)

  • Irene L. Andrulis

    (Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
    University of Toronto, Toronto, Ontario M5S 1A8, Canada.)

  • Hoda Anton-Culver

    (University of California Irvine)

  • Femke Atsma

    (Sanquin Research, 6525 GA Nijmegen, The Netherlands.)

  • Stefania Bandinelli

    (Tuscany Regional Health Agency, Florence, Italy, University of Florence, 50134 Florence, Italy.
    Geriatric Unit, Azienda Sanitaria di Firenze, 50122 Florence, Italy.)

  • Matthias W. Beckmann

    (University Breast Center Franconia, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, D-91054 Erlangen, Germany.)

  • Javier Benitez

    (Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), E-28029 Madrid, Spain.
    Centro de Investigación en Red de Enfermedades Raras (CIBERER), E-46010 Valencia, Spain.)

  • Carl Blomqvist

    (University of Helsinki and Helsinki University Central Hospital, FI-00100 Helsinki, Finland.)

  • Stig E. Bojesen

    (Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, DK-2100 Copenhagen, Denmark.
    Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, DK-2100 Copenhagen, Denmark.)

  • Manjeet K. Bolla

    (Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.)

  • Bernardo Bonanni

    (Istituto Europeo di Oncologia (IEO), 20139 Milan, Italy.)

  • Hiltrud Brauch

    (DrMargarete Fischer-Bosch-Institute of Clinical Pharmacology, D-70376 Stuttgart, Germany.
    University of Tübingen, D-72074 Tübingen, Germany.)

  • Hermann Brenner

    (German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany.
    German Cancer Consortium (DKTK), D-69120 Heidelberg, Germany.)

  • Julie E. Buring

    (Brigham and Women’s Hospital
    Harvard Medical School)

  • Jenny Chang-Claude

    (German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany.)

  • Stephen Chanock

    (National Cancer Institute)

  • Jinhui Chen

    (Indiana University school of Medicine
    Stark Neuroscience Research Center, Indiana University school of Medicine)

  • Georgia Chenevix-Trench

    (QIMR Berghofer Medical Research Institute)

  • J. Margriet Collée

    (Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.)

  • Fergus J. Couch

    (Mayo Clinic)

  • David Couper

    (University of North Carolina)

  • Andrea D. Coviello

    (Boston University School of Medicine, Sections of Preventive Medicine and Endocrinology)

  • Angela Cox

    (Sheffield Cancer Research Centre, University of Sheffield, Sheffield S10 2RX, UK.)

  • Kamila Czene

    (Karolinska Institutet, 17177 Stockholm, Sweden.)

  • Adamo Pio D’adamo

    (Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”, 34137 Trieste, Italy.
    Surgical and Health, University of Trieste, 34149 Trieste, Italy.)

  • George Davey Smith

    (MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK.
    School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.)

  • Immaculata De Vivo

    (Harvard School of Public Health
    Brigham and Women’s Hospital and Harvard Medical School)

  • Ellen W. Demerath

    (School of Public Health, University of Minnesota)

  • Joe Dennis

    (Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.)

  • Peter Devilee

    (Leiden University Medical Center, 2300 RC Leiden, The Netherlands.)

  • Aida K. Dieffenbach

    (German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany.
    German Cancer Consortium (DKTK), D-69120 Heidelberg, Germany.)

  • Alison M. Dunning

    (Centre for Cancer Genetic Epidemiology, University of Cambridge CB1 8RN, UK.)

  • Gudny Eiriksdottir

    (Icelandic Heart Association, IS-201 Kopavogur, Iceland.)

  • Johan G. Eriksson

    (National Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland.
    University of Helsinki, FI-00014 Helsinki, Finland.
    Helsinki University Central Hospital, Unit of General Practice, FI-00029 HUS Helsinki, Finland.
    Folkhalsan Research Centre, FI-00290 Helsinki, Finland.)

  • Peter A. Fasching

    (University Breast Center Franconia, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, D-91054 Erlangen, Germany.)

  • Luigi Ferrucci

    (Longitudinal Studies Section, Clinical Research Branch, Gerontology Research Center, National Institute on Aging)

  • Dieter Flesch-Janys

    (University Clinic Hamburg-Eppendorf, D-20246 Hamburg, Germany.)

  • Henrik Flyger

    (Herlev Hospital, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.)

  • Tatiana Foroud

    (Indiana University School of Medicine)

  • Lude Franke

    (University of Groningen, University Medical Centre Groningen, P.O. Box 72, 9700 AB Groningen, The Netherlands.)

  • Melissa E. Garcia

    (National Insitute on Aging, National Institutes of Health)

  • Montserrat García-Closas

    (Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.
    Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.)

  • Frank Geller

    (Statens Serum Institut, DK-2300 Copenhagen, Denmark.)

  • Eco E. J. de Geus

    (VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
    EMGO + Institute for Health and Care Research, VU University Medical Centre, Van der Boechorststraat 7, 1081 Bt, Amsterdam, The Netherlands.)

  • Graham G. Giles

    (Cancer Epidemiology Centre, Cancer Council Victoria
    Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne)

  • Daniel F. Gudbjartsson

    (deCODE Genetics, Reykjavik IS-101, Iceland.
    Faculty of Medicine, University of Iceland, IS-101 Reykjavik, Iceland.)

  • Vilmundur Gudnason

    (Icelandic Heart Association, IS-201 Kopavogur, Iceland.
    University of Iceland, IS-101 Reykjavik, Iceland.)

  • Pascal Guénel

    (Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, F-94807 Villejuif, France.
    University Paris-Sud, UMRS 1018, F-94807 Villejuif, France.)

  • Suiqun Guo

    (Southern Medical University)

  • Per Hall

    (Karolinska Institutet, 17177 Stockholm, Sweden.)

  • Ute Hamann

    (Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), D-69120 Heidelberg, Germany.)

  • Robin Haring

    (Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany.)

  • Catharina A. Hartman

    (University of Groningen, University Medical Center Groningen, P.O. Box 72, 9700 AB Groningen, The Netherlands.)

  • Andrew C. Heath

    (Washington University)

  • Albert Hofman

    (Erasmus MC, PO Box 2040, 3000 CA Rotterdam, the Netherlands.)

  • Maartje J. Hooning

    (Erasmus University Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.)

  • John L. Hopper

    (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne)

  • Frank B. Hu

    (Harvard School of Public Health
    Brigham and Women’s Hospital and Harvard Medical School
    Harvard School of Public Health)

  • David J. Hunter

    (Broad Institute of the Massachusetts Institute of Technology and Harvard University
    Harvard School of Public Health
    Brigham and Women’s Hospital and Harvard Medical School)

  • David Karasik

    (Harvard Medical School
    Hebrew SeniorLife Institute for Aging Research)

  • Douglas P. Kiel

    (Hebrew SeniorLife Institute for Aging Research
    Beth Israel Deaconess Medical Center and Harvard Medical School)

  • Julia A. Knight

    (Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
    Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario M5T 3M7, Canada.)

  • Veli-Matti Kosma

    (School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.
    Imaging Center, Kuopio University Hospital, P.O. Box 100, FI-70029 Kuopio, Finland.)

  • Zoltan Kutalik

    (University of Lausanne, CH-1005 Lausanne, Switzerland.
    Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland.)

  • Sandra Lai

    (Institute of Genetics and Biomedical Research, National Research Council, Cagliari, 09042 Sardinia, Italy.)

  • Diether Lambrechts

    (Vesalius Research Center (VRC), VIB, 3000 Leuven, Belgium.
    Laboratory for Translational Genetics, University of Leuven, 3000 Leuven, Belgium.)

  • Annika Lindblom

    (Karolinska Institutet, SE-171 77 Stockholm, Sweden.)

  • Reedik Mägi

    (Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.)

  • Patrik K. Magnusson

    (Karolinska Institutet, 17177 Stockholm, Sweden.)

  • Arto Mannermaa

    (School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.
    Imaging Center, Kuopio University Hospital, P.O. Box 100, FI-70029 Kuopio, Finland.)

  • Nicholas G. Martin

    (QIMR Berghofer Medical Research Institute)

  • Gisli Masson

    (deCODE Genetics, Reykjavik IS-101, Iceland.)

  • Patrick F. McArdle

    (Program in Personalized and Genomic Medicine, Diabetes and Nutrition, University of Maryland School of Medicine)

  • Wendy L. McArdle

    (School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.)

  • Mads Melbye

    (Statens Serum Institut, DK-2300 Copenhagen, Denmark.
    Stanford School of Medicine)

  • Kyriaki Michailidou

    (Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.)

  • Evelin Mihailov

    (Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
    University of Tartu, 51010 Tartu, Estonia.)

  • Lili Milani

    (Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.)

  • Roger L. Milne

    (Cancer Epidemiology Centre, Cancer Council Victoria
    Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne)

  • Heli Nevanlinna

    (University of Helsinki and Helsinki University Central Hospital, P.O. Box 100, FI-00029 HUS Helsinki, Finland.)

  • Patrick Neven

    (KULeuven (University of Leuven), Multidisciplinary Breast Center, University Hospitals Leuven, 3000 Leuven, Belgium.)

  • Ellen A. Nohr

    (Research Unit of Obstetrics & Gynecology, Institute of Clinical Research, University of Southern Denmark, DK-5000 Odense C, Denmark.)

  • Albertine J. Oldehinkel

    (Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.)

  • Ben A. Oostra

    (Erasmus MC, 3015 GE, Rotterdam, the Netherlands.)

  • Aarno Palotie

    (Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI-00014, Finland.
    Analytic and Translational Genetics Unit, Massachusetts General Hospital
    Program in Medical and Population Genetics, Broad Institute
    Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital)

  • Munro Peacock

    (Indiana University School of Medicine)

  • Nancy L. Pedersen

    (Karolinska Institutet, 17177 Stockholm, Sweden.)

  • Paolo Peterlongo

    (IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, 20139 Milan, Italy.)

  • Julian Peto

    (London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.)

  • Paul D. P. Pharoah

    (Centre for Cancer Genetic Epidemiology, University of Cambridge CB1 8RN, UK.)

  • Dirkje S. Postma

    (University Groningen, University Medical Center Groningen, GRIAC Research Institute, P.O. Box 30.001, NL-9700 RB Groningen, The Netherlands.)

  • Anneli Pouta

    (National Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland.
    Oulu University Hospital, P.O. Box 10, FI-90029 OYS Oulu, Finland.)

  • Katri Pylkäs

    (Laboratory of Cancer Genetics and Tumor Biology, University of Oulu, Oulu University Hospital/NordLab Oulu, P.O. Box 3000, FI-90014 Oulu, Finland.)

  • Paolo Radice

    (Unit of Molecular Bases of Genetic Risk and Genetic Testing, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), 20133 Milan, Italy.)

  • Susan Ring

    (MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK.
    School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.)

  • Fernando Rivadeneira

    (Erasmus MC, 3015 GE Rotterdam, the Netherlands.
    Netherlands Consortium on Health Aging and National Genomics Initiative, 2300 RC Leiden, the Netherlands.
    Erasmus MC, PO Box 2040, 3000 CA Rotterdam, the Netherlands.)

  • Antonietta Robino

    (Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”, 34137 Trieste, Italy.
    Surgical and Health, University of Trieste, 34149 Trieste, Italy.)

  • Lynda M. Rose

    (Brigham and Women’s Hospital)

  • Anja Rudolph

    (German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany.)

  • Veikko Salomaa

    (National Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland.)

  • Serena Sanna

    (Institute of Genetics and Biomedical Research, National Research Council, Cagliari, 09042 Sardinia, Italy.)

  • David Schlessinger

    (National Institute on Aging, Intramural Research Program)

  • Marjanka K. Schmidt

    (Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Postbus 90203, 1006 BE Amsterdam, The Netherlands.)

  • Mellissa C. Southey

    (The University of Melbourne)

  • Ulla Sovio

    (MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.
    University of Cambridge, Cambridge CB2 0SW, UK.)

  • Meir J. Stampfer

    (Harvard School of Public Health
    Brigham and Women’s Hospital and Harvard Medical School
    Harvard School of Public Health)

  • Doris Stöckl

    (Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, D-8576 Neuherberg, Germany.
    Campus Grosshadern, Ludwig-Maximilians-University, D-81377 Munich, Germany.)

  • Anna M. Storniolo

    (Indiana University School of Medicine)

  • Nicholas J. Timpson

    (MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK.
    School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.)

  • Jonathan Tyrer

    (Centre for Cancer Genetic Epidemiology, University of Cambridge CB1 8RN, UK.)

  • Jenny A. Visser

    (Erasmus MC, 3015 GE Rotterdam, the Netherlands.)

  • Peter Vollenweider

    (Lausanne University Hospital, CH-1015 Lausanne, Switzerland.)

  • Henry Völzke

    (Institute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany.
    DZHK (German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany.)

  • Gerard Waeber

    (Lausanne University Hospital, CH-1015 Lausanne, Switzerland.)

  • Melanie Waldenberger

    (Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-8576 Neuherberg, Germany.)

  • Henri Wallaschofski

    (Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany.
    DZHK (German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany.)

  • Qin Wang

    (Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.)

  • Gonneke Willemsen

    (VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.)

  • Robert Winqvist

    (Laboratory of Cancer Genetics and Tumor Biology, University of Oulu, Oulu University Hospital/NordLab Oulu, P.O. Box 3000, FI-90014 Oulu, Finland.)

  • Bruce H. R. Wolffenbuttel

    (University of Groningen, University Medical Centre Groningen, P.O. Box 72, 9700 AB Groningen, The Netherlands.)

  • Margaret J. Wright

    (Queensland Insitute of Medical Research)

  • Dorret I. Boomsma

    (VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.)

  • Michael J. Econs

    (Indiana University School of Medicine
    Indiana University School of Medicine)

  • Kay-Tee Khaw

    (Institute of Public Health, University of Cambridge, Cambridge CB2 0QQ, UK.)

  • Ruth J. F. Loos

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
    Genetics of Obesity and Related Metabolic Traits Program, The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, Box 1003, New York, New York 10029, USA.)

  • Mark I. McCarthy

    (Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
    NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford OX3 7LE, UK.
    Oxford Centre for Diabetes, Endocrinology, & Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK.)

  • Grant W. Montgomery

    (Queensland Insitute of Medical Research)

  • John P. Rice

    (Washington University)

  • Elizabeth A. Streeten

    (Program in Personalized and Genomic Medicine, Diabetes and Nutrition, University of Maryland School of Medicine
    Geriatric Research and Education Clinical Center (GRECC) - Veterans Administration Medical Center)

  • Unnur Thorsteinsdottir

    (deCODE Genetics, Reykjavik IS-101, Iceland.
    Faculty of Medicine, University of Iceland, IS-101 Reykjavik, Iceland.)

  • Cornelia M. van Duijn

    (Netherlands Consortium on Health Aging and National Genomics Initiative, 2300 RC Leiden, the Netherlands.
    Erasmus MC, 3015 GE, Rotterdam, the Netherlands.
    Centre of Medical Systems Biology, PO Box 9600, 2300 RC Leiden, the Netherlands.)

  • Behrooz Z. Alizadeh

    (University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.)

  • Sven Bergmann

    (University of Lausanne, CH-1005 Lausanne, Switzerland.
    Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland.)

  • Eric Boerwinkle

    (Human Genetics Center and Divof Epidemiology, University of Houston, P.O. Box 20186, Texas 77025 USA.)

  • Heather A. Boyd

    (Statens Serum Institut, DK-2300 Copenhagen, Denmark.)

  • Laura Crisponi

    (Institute of Genetics and Biomedical Research, National Research Council, Cagliari, 09042 Sardinia, Italy.)

  • Paolo Gasparini

    (Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”, 34137 Trieste, Italy.
    Surgical and Health, University of Trieste, 34149 Trieste, Italy.)

  • Christian Gieger

    (Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.)

  • Tamara B. Harris

    (National Insitute on Aging, National Institutes of Health)

  • Erik Ingelsson

    (Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Box 256, 751 05 Uppsala, Sweden.)

  • Marjo-Riitta Järvelin

    (MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.
    Institute of Health Sciences, University of Oulu, P.O. Box 5000, FI-90014 Oulu, Finland.
    Biocenter Oulu, University of Oulu, P.O. Box 5000, Aapistie 5A, FI-90014 Oulu, Finland.
    National Institute for Health and Welfare, Aapistie 1, Box 310, FI-90101 Oulu, Finland.)

  • Peter Kraft

    (Harvard School of Public Health
    Harvard School of Public Health)

  • Debbie Lawlor

    (MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK.
    School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.)

  • Andres Metspalu

    (Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
    University of Tartu, 51010 Tartu, Estonia.)

  • Craig E. Pennell

    (School of Women’s and Infants’ Health, The University of Western Australia, WA-6009, Australia.)

  • Paul M. Ridker

    (Brigham and Women’s Hospital
    Harvard Medical School)

  • Harold Snieder

    (University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.)

  • Thorkild I. A. Sørensen

    (Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200, Denmark.
    Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Copenhagen, DK-2000 Frederiksberg, Denmark.)

  • Tim D. Spector

    (King’s College London, London SE1 7EH, UK.)

  • David P. Strachan

    (St George’s, University of London, Cranmer Terrace, London SW17 0RE, UK.)

  • André G. Uitterlinden

    (Erasmus MC, 3015 GE Rotterdam, the Netherlands.
    Netherlands Consortium on Health Aging and National Genomics Initiative, 2300 RC Leiden, the Netherlands.
    Erasmus MC, PO Box 2040, 3000 CA Rotterdam, the Netherlands.)

  • Nicholas J. Wareham

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.)

  • Elisabeth Widen

    (Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI-00014, Finland.)

  • Marek Zygmunt

    (University Medicine Greifswald, D-17475 Greifswald, Germany.)

  • Anna Murray

    (University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.)

  • Douglas F. Easton

    (Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.)

  • Kari Stefansson

    (deCODE Genetics, Reykjavik IS-101, Iceland.
    Faculty of Medicine, University of Iceland, IS-101 Reykjavik, Iceland.)

  • Joanne M. Murabito

    (NHLBI’s and Boston University’s Framingham Heart Study
    Boston University School of Medicine, Section of General Internal Medicine)

  • Ken K. Ong

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
    University of Cambridge, Cambridge CB2 0QQ, UK.)

Abstract

Here 106 genomic loci associated with age at menarche, a marker of puberty timing in females, are identified; these loci show enrichment for genes involved in nuclear hormone receptor function, body mass index, and rare disorders of puberty, and for genes located in imprinted regions, with parent-of-origin specific effects at several loci.

Suggested Citation

  • John R. B. Perry & Felix Day & Cathy E. Elks & Patrick Sulem & Deborah J. Thompson & Teresa Ferreira & Chunyan He & Daniel I. Chasman & Tõnu Esko & Gudmar Thorleifsson & Eva Albrecht & Wei Q. Ang & Ta, 2014. "Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche," Nature, Nature, vol. 514(7520), pages 92-97, October.
    • Handle: RePEc:nat:nature:v:514:y:2014:i:7520:d:10.1038_nature13545
    DOI: 10.1038/nature13545
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