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DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier

Author

Listed:
  • Margarida A. Santos

    (Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health)

  • Robert B. Faryabi

    (Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health)

  • Aysegul V. Ergen

    (Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health)

  • Amanda M. Day

    (Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health)

  • Amy Malhowski

    (Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health)

  • Andres Canela

    (Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health)

  • Masahiro Onozawa

    (The Genetics Branch, National Cancer Institute, National Institutes of Health)

  • Ji-Eun Lee

    (Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health)

  • Elsa Callen

    (Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health)

  • Paula Gutierrez-Martinez

    (Program in Cellular and Molecular Medicine, Boston Children’s Hospital
    Harvard University)

  • Hua-Tang Chen

    (Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health)

  • Nancy Wong

    (Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health)

  • Nadia Finkel

    (Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health)

  • Aniruddha Deshpande

    (Memorial Sloan-Kettering Cancer Center)

  • Susan Sharrow

    (Experimental Immunology Branch, National Cancer Institute, National Institutes of Health)

  • Derrick J. Rossi

    (Program in Cellular and Molecular Medicine, Boston Children’s Hospital
    Harvard University)

  • Keisuke Ito

    (Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein Cancer Center, Albert Einstein College of Medicine)

  • Kai Ge

    (Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health)

  • Peter D. Aplan

    (The Genetics Branch, National Cancer Institute, National Institutes of Health)

  • Scott A. Armstrong

    (Memorial Sloan-Kettering Cancer Center)

  • André Nussenzweig

    (Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health)

Abstract

Histone methyl-transferase MLL4 is required for stem-cell activity and an aggressive form of acute myeloid leukaemia harbouring the MLL–AF9 oncogene.

Suggested Citation

  • Margarida A. Santos & Robert B. Faryabi & Aysegul V. Ergen & Amanda M. Day & Amy Malhowski & Andres Canela & Masahiro Onozawa & Ji-Eun Lee & Elsa Callen & Paula Gutierrez-Martinez & Hua-Tang Chen & Na, 2014. "DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier," Nature, Nature, vol. 514(7520), pages 107-111, October.
    • Handle: RePEc:nat:nature:v:514:y:2014:i:7520:d:10.1038_nature13483
    DOI: 10.1038/nature13483
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    Cited by:

    1. Natthakan Thongon & Feiyang Ma & Andrea Santoni & Matteo Marchesini & Elena Fiorini & Ashley Rose & Vera Adema & Irene Ganan-Gomez & Emma M. Groarke & Fernanda Gutierrez-Rodrigues & Shuaitong Chen & P, 2021. "Hematopoiesis under telomere attrition at the single-cell resolution," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    2. Wei Liu & Hongchao Cao & Jing Wang & Areeg Elmusrati & Bing Han & Wei Chen & Ping Zhou & Xiyao Li & Stephen Keysar & Antonio Jimeno & Cun-Yu Wang, 2024. "Histone-methyltransferase KMT2D deficiency impairs the Fanconi anemia/BRCA pathway upon glycolytic inhibition in squamous cell carcinoma," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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