IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v513y2014i7519d10.1038_nature13627.html
   My bibliography  Save this article

Joiner et al. reply

Author

Listed:
  • Mei-ling A. Joiner

    (Carver College of Medicine, University of Iowa
    Present addresses: Department of Molecular Physiology & Biophysics, Carver College of Medicine, University of Iowa, 51 Newton Road, Iowa City, Iowa 52242, USA (M.A.J.); The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA (J.L., P.J.M.); Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA (B.J.H.); Johns Hopkins University School of Medicine, 1830 East Monument Street, 9th Floor, Suite 9026, Baltimore, Maryland 21287, USA (E.D.L., M.E.A.))

  • Olha M. Koval

    (Carver College of Medicine, University of Iowa)

  • Jingdong Li

    (Carver College of Medicine, University of Iowa
    Present addresses: Department of Molecular Physiology & Biophysics, Carver College of Medicine, University of Iowa, 51 Newton Road, Iowa City, Iowa 52242, USA (M.A.J.); The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA (J.L., P.J.M.); Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA (B.J.H.); Johns Hopkins University School of Medicine, 1830 East Monument Street, 9th Floor, Suite 9026, Baltimore, Maryland 21287, USA (E.D.L., M.E.A.))

  • B. Julie He

    (Carver College of Medicine, University of Iowa
    Present addresses: Department of Molecular Physiology & Biophysics, Carver College of Medicine, University of Iowa, 51 Newton Road, Iowa City, Iowa 52242, USA (M.A.J.); The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA (J.L., P.J.M.); Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA (B.J.H.); Johns Hopkins University School of Medicine, 1830 East Monument Street, 9th Floor, Suite 9026, Baltimore, Maryland 21287, USA (E.D.L., M.E.A.))

  • Chantal Allamargot

    (University of Iowa Central Microscopy Research Facility, Carver College of Medicine, University of Iowa)

  • Zhan Gao

    (Carver College of Medicine, University of Iowa)

  • Elizabeth D. Luczak

    (Carver College of Medicine, University of Iowa
    Present addresses: Department of Molecular Physiology & Biophysics, Carver College of Medicine, University of Iowa, 51 Newton Road, Iowa City, Iowa 52242, USA (M.A.J.); The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA (J.L., P.J.M.); Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA (B.J.H.); Johns Hopkins University School of Medicine, 1830 East Monument Street, 9th Floor, Suite 9026, Baltimore, Maryland 21287, USA (E.D.L., M.E.A.))

  • Duane D. Hall

    (Carver College of Medicine, University of Iowa)

  • Brian D. Fink

    (Iowa City Veterans Affairs Medical)

  • Biyi Chen

    (Carver College of Medicine, University of Iowa)

  • Jinying Yang

    (Carver College of Medicine, University of Iowa)

  • Steven A. Moore

    (Carver College of Medicine, University of Iowa
    Carver College of Medicine, University of Iowa)

  • Thomas D. Scholz

    (Carver College of Medicine, University of Iowa)

  • Stefan Strack

    (Carver College of Medicine, University of Iowa)

  • Peter J. Mohler

    (Carver College of Medicine, University of Iowa
    Present addresses: Department of Molecular Physiology & Biophysics, Carver College of Medicine, University of Iowa, 51 Newton Road, Iowa City, Iowa 52242, USA (M.A.J.); The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA (J.L., P.J.M.); Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA (B.J.H.); Johns Hopkins University School of Medicine, 1830 East Monument Street, 9th Floor, Suite 9026, Baltimore, Maryland 21287, USA (E.D.L., M.E.A.))

  • William I. Sivitz

    (Carver College of Medicine, University of Iowa
    Iowa City Veterans Affairs Medical)

  • Long-Sheng Song

    (Carver College of Medicine, University of Iowa)

  • Mark E. Anderson

    (Carver College of Medicine, University of Iowa
    Carver College of Medicine, University of Iowa
    Present addresses: Department of Molecular Physiology & Biophysics, Carver College of Medicine, University of Iowa, 51 Newton Road, Iowa City, Iowa 52242, USA (M.A.J.); The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA (J.L., P.J.M.); Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA (B.J.H.); Johns Hopkins University School of Medicine, 1830 East Monument Street, 9th Floor, Suite 9026, Baltimore, Maryland 21287, USA (E.D.L., M.E.A.))

Abstract

Replying to F. Fieni et al. Nature 513, 10.1038/nature13626 (2014) In our Letter1 identifying mitochondrial CaMKII as a crucial component of a Ca2+-dependent process of heart disease, we used multiple methods to show that CaMKII modulates mitochondrial Ca2+ homeostasis, as outlined below. First, we carried out electrophysiology of the mitochondrial calcium uniporter (MCU) current in mitoplasts. In our report1 we did not claim to measure capacitance of the mitoplast separately from the total capacitance of the mitoplast and pipette. Although we concede that the approach of Fieni et al.2 is preferable, we found that even after removing any correction for capacitance, dialysis with constitutively active CaMKII monomers increased MCU current whereas dialysis with catalytically dead CaMKII monomers did not.

Suggested Citation

  • Mei-ling A. Joiner & Olha M. Koval & Jingdong Li & B. Julie He & Chantal Allamargot & Zhan Gao & Elizabeth D. Luczak & Duane D. Hall & Brian D. Fink & Biyi Chen & Jinying Yang & Steven A. Moore & Thom, 2014. "Joiner et al. reply," Nature, Nature, vol. 513(7519), pages 3-3, September.
    • Handle: RePEc:nat:nature:v:513:y:2014:i:7519:d:10.1038_nature13627
    DOI: 10.1038/nature13627
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature13627
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature13627?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:513:y:2014:i:7519:d:10.1038_nature13627. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.