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The alarmin IL-33 promotes regulatory T-cell function in the intestine

Author

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  • Chris Schiering

    (Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
    Present addresses: Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK (C.S.); Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, University at Buffalo (SUNY), Buffalo, New York 14214-3000, USA (E.A.W.).)

  • Thomas Krausgruber

    (Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK)

  • Agnieszka Chomka

    (Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK)

  • Anja Fröhlich

    (Experimental Immunology, Charité — University Medicine Berlin, and German Rheumatism Research Center (DRFZ), D-10117 Berlin, Germany)

  • Krista Adelmann

    (Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK)

  • Elizabeth A. Wohlfert

    (Program in Barrier Immunity and Repair, Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH)
    Present addresses: Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK (C.S.); Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, University at Buffalo (SUNY), Buffalo, New York 14214-3000, USA (E.A.W.).)

  • Johanna Pott

    (Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK)

  • Thibault Griseri

    (Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK)

  • Julia Bollrath

    (Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK)

  • Ahmed N. Hegazy

    (Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK)

  • Oliver J. Harrison

    (Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK)

  • Benjamin M. J. Owens

    (Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK)

  • Max Löhning

    (Experimental Immunology, Charité — University Medicine Berlin, and German Rheumatism Research Center (DRFZ), D-10117 Berlin, Germany)

  • Yasmine Belkaid

    (Program in Barrier Immunity and Repair, Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH))

  • Padraic G. Fallon

    (Trinity Biomedical Sciences Institute, Trinity College Dublin, Pearse Street, Dublin 2, Ireland)

  • Fiona Powrie

    (Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK)

Abstract

The alarmin interleukin-33 is constitutively expressed at barrier sites and released in response to tissue damage; here, the IL-33 receptor ST2 is shown to be preferentially expressed on colonic regulatory T cells, where it promotes regulatory T-cell function and adaptation to the inflammatory tissue environment.

Suggested Citation

  • Chris Schiering & Thomas Krausgruber & Agnieszka Chomka & Anja Fröhlich & Krista Adelmann & Elizabeth A. Wohlfert & Johanna Pott & Thibault Griseri & Julia Bollrath & Ahmed N. Hegazy & Oliver J. Harri, 2014. "The alarmin IL-33 promotes regulatory T-cell function in the intestine," Nature, Nature, vol. 513(7519), pages 564-568, September.
    • Handle: RePEc:nat:nature:v:513:y:2014:i:7519:d:10.1038_nature13577
    DOI: 10.1038/nature13577
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    Cited by:

    1. Zhaoyun Ding & Ting Cai & Jupei Tang & Hanxiao Sun & Xinyi Qi & Yunpeng Zhang & Yan Ji & Liyun Yuan & Huidan Chang & Yanhui Ma & Hong Zhou & Li Li & Huiming Sheng & Ju Qiu, 2022. "Setd2 supports GATA3+ST2+ thymic-derived Treg cells and suppresses intestinal inflammation," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Anhao Liu & Mikihito Hayashi & Yujin Ohsugi & Sayaka Katagiri & Shizuo Akira & Takanori Iwata & Tomoki Nakashima, 2024. "The IL-33/ST2 axis is protective against acute inflammation during the course of periodontitis," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Yingying Shen & Chaojie Lu & Zhengbo Song & Chenxiao Qiao & Jiaoli Wang & Jinbiao Chen & Chengyan Zhang & Xianchang Zeng & Zeyu Ma & Tao Chen & Xu Li & Aifu Lin & Jufeng Guo & Jianli Wang & Zhijian Ca, 2022. "Ursodeoxycholic acid reduces antitumor immunosuppression by inducing CHIP-mediated TGF-β degradation," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Seymour Picciotto & Nicholas DeVita & Chiaowen Joyce Hsiao & Christopher Honan & Sze-Wah Tse & Mychael Nguyen & Joseph D. Ferrari & Wei Zheng & Brian T. Wipke & Eric Huang, 2022. "Selective activation and expansion of regulatory T cells using lipid encapsulated mRNA encoding a long-acting IL-2 mutein," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    5. Marco Calafiore & Ya-Yuan Fu & Paola Vinci & Viktor Arnhold & Winston Y. Chang & Suze A. Jansen & Anastasiya Egorova & Shuichiro Takashima & Jason Kuttiyara & Takahiro Ito & Jonathan Serody & Susumu N, 2023. "A tissue-intrinsic IL-33/EGF circuit promotes epithelial regeneration after intestinal injury," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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