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Antifungal drug resistance evoked via RNAi-dependent epimutations

Author

Listed:
  • Silvia Calo

    (Duke University Medical Center)

  • Cecelia Shertz-Wall

    (Duke University Medical Center)

  • Soo Chan Lee

    (Duke University Medical Center)

  • Robert J. Bastidas

    (Duke University Medical Center)

  • Francisco E. Nicolás

    (Regional Campus of International Excellence “Campus Mare Nostrum”, Murcia 30100, Spain
    Faculty of Biology, University of Murcia, Murcia 30100, Spain)

  • Joshua A. Granek

    (Duke University Medical Center
    Duke University Medical Center
    Duke Center for the Genomics of Microbial Systems, Duke University Medical Center)

  • Piotr Mieczkowski

    (High-Throughput Sequencing Facility, University of North Carolina)

  • Santiago Torres-Martínez

    (Faculty of Biology, University of Murcia, Murcia 30100, Spain)

  • Rosa M. Ruiz-Vázquez

    (Faculty of Biology, University of Murcia, Murcia 30100, Spain)

  • Maria E. Cardenas

    (Duke University Medical Center)

  • Joseph Heitman

    (Duke University Medical Center)

Abstract

The human fungal pathogen Mucor circinelloides develops spontaneous resistance to an antifungal drug both through mutation and through a newly identified epigenetic RNA-mediated pathway; RNA interference is spontaneously triggered to silence the fkbA gene, giving rise to drug-resistant epimutants that revert to being drug-sensitive once again when grown in the absence of drug.

Suggested Citation

  • Silvia Calo & Cecelia Shertz-Wall & Soo Chan Lee & Robert J. Bastidas & Francisco E. Nicolás & Joshua A. Granek & Piotr Mieczkowski & Santiago Torres-Martínez & Rosa M. Ruiz-Vázquez & Maria E. Cardena, 2014. "Antifungal drug resistance evoked via RNAi-dependent epimutations," Nature, Nature, vol. 513(7519), pages 555-558, September.
    • Handle: RePEc:nat:nature:v:513:y:2014:i:7519:d:10.1038_nature13575
    DOI: 10.1038/nature13575
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    Cited by:

    1. Nicholas C. Gervais & Rebecca S. Shapiro, 2024. "Discovering the hidden function in fungal genomes," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Carlos Lax & Stephen J. Mondo & Macario Osorio-Concepción & Anna Muszewska & María Corrochano-Luque & Gabriel Gutiérrez & Robert Riley & Anna Lipzen & Jie Guo & Hope Hundley & Mojgan Amirebrahimi & Vi, 2024. "Symmetric and asymmetric DNA N6-adenine methylation regulates different biological responses in Mucorales," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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