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GATM gene variants and statin myopathy risk

Author

Listed:
  • D. F. Carr

    (Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, 1–5 Brownlow Street, Liverpool L69 3GL, UK)

  • A. Alfirevic

    (Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, 1–5 Brownlow Street, Liverpool L69 3GL, UK)

  • R. Johnson

    (Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, 1–5 Brownlow Street, Liverpool L69 3GL, UK)

  • H. Chinoy

    (NIHR Manchester Musculoskeletal Biomedical Research Unit, Institute of Inflammation and Repair, University of Manchester, Oxford Road, Manchester M13 9PT, UK)

  • T. van Staa

    (Health eResearch Centre, Farr Institute for Health Informatics Research, University of Manchester, 1.311 Jean McFarlane Building, Oxford Road, Manchester M13 9PL, UK)

  • M. Pirmohamed

    (Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, 1–5 Brownlow Street, Liverpool L69 3GL, UK)

Abstract

Arising from L. M. Mangravite et al. Nature 502, 377–380 (2013); doi:10.1038/nature12508 Mangravite et al.1 identified six expression quantitative loci (eQTLs) that interacted with simvastatin exposure by using 480 lymphoblastoid cell lines exposed to β-hydroxy simvastatin acid in vitro. One of these SNPs (rs9806699) within the glycine amidinotransferase (GATM) gene was shown to have an association with statin-induced myopathy in two independent cohorts (n = 172 myopathy cases), conferring a protective effect (odds ratio = 0.61, 95% confidence interval = 0.39–0.95, P = 0.03). Our genotyping results from statin myopathy patients do not appear to replicate this finding. There is a Reply to this Brief Communication Arising by Mangravite, L. M. et al. Nature 513, http://dx.doi.org/10.1038/nature13630 (2014).

Suggested Citation

  • D. F. Carr & A. Alfirevic & R. Johnson & H. Chinoy & T. van Staa & M. Pirmohamed, 2014. "GATM gene variants and statin myopathy risk," Nature, Nature, vol. 513(7518), pages 1-1, September.
    • Handle: RePEc:nat:nature:v:513:y:2014:i:7518:d:10.1038_nature13628
    DOI: 10.1038/nature13628
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    Cited by:

    1. James S Floyd & Katarzyna M Bloch & Jennifer A Brody & Cyrielle Maroteau & Moneeza K Siddiqui & Richard Gregory & Daniel F Carr & Mariam Molokhia & Xiaoming Liu & Joshua C Bis & Ammar Ahmed & Xuan Liu, 2019. "Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing," PLOS ONE, Public Library of Science, vol. 14(6), pages 1-13, June.

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