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Coordinated regulation of protein synthesis and degradation by mTORC1

Author

Listed:
  • Yinan Zhang

    (Harvard School of Public Health)

  • Justin Nicholatos

    (Harvard School of Public Health)

  • John R. Dreier

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Stéphane J. H. Ricoult

    (Harvard School of Public Health)

  • Scott B. Widenmaier

    (Harvard School of Public Health)

  • Gökhan S. Hotamisligil

    (Harvard School of Public Health)

  • David J. Kwiatkowski

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Brendan D. Manning

    (Harvard School of Public Health)

Abstract

mTORC1 is known to stimulate protein synthesis; now, it is shown to also promote the synthesis of proteasomes, which degrade proteins into the amino acids needed to create new proteins.

Suggested Citation

  • Yinan Zhang & Justin Nicholatos & John R. Dreier & Stéphane J. H. Ricoult & Scott B. Widenmaier & Gökhan S. Hotamisligil & David J. Kwiatkowski & Brendan D. Manning, 2014. "Coordinated regulation of protein synthesis and degradation by mTORC1," Nature, Nature, vol. 513(7518), pages 440-443, September.
    • Handle: RePEc:nat:nature:v:513:y:2014:i:7518:d:10.1038_nature13492
    DOI: 10.1038/nature13492
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    Cited by:

    1. Maxime Uriarte & Nadine Nkwe & Roch Tremblay & Oumaima Ahmed & Clémence Messmer & Nazar Mashtalir & Haithem Barbour & Louis Masclef & Marion Voide & Claire Viallard & Salima Daou & Djaileb Abdelhadi &, 2021. "Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis," Nature Communications, Nature, vol. 12(1), pages 1-22, December.

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