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Fructose-1,6-bisphosphatase opposes renal carcinoma progression

Author

Listed:
  • Bo Li

    (Abramson Family Cancer Research Institute, University of Pennsylvania)

  • Bo Qiu

    (Abramson Family Cancer Research Institute, University of Pennsylvania)

  • David S. M. Lee

    (Abramson Family Cancer Research Institute, University of Pennsylvania
    Howard Hughes Medical Institute)

  • Zandra E. Walton

    (Abramson Family Cancer Research Institute, University of Pennsylvania
    University of Pennsylvania)

  • Joshua D. Ochocki

    (Abramson Family Cancer Research Institute, University of Pennsylvania)

  • Lijoy K. Mathew

    (Abramson Family Cancer Research Institute, University of Pennsylvania
    Howard Hughes Medical Institute)

  • Anthony Mancuso

    (Abramson Family Cancer Research Institute, University of Pennsylvania
    University of Pennsylvania
    Perelman School of Medicine at the University of Pennsylvania)

  • Terence P. F. Gade

    (Perelman School of Medicine at the University of Pennsylvania)

  • Brian Keith

    (Abramson Family Cancer Research Institute, University of Pennsylvania
    University of Pennsylvania)

  • Itzhak Nissim

    (Biochemistry and Biophysics, University of Pennsylvania
    Children's Hospital of Philadelphia)

  • M. Celeste Simon

    (Abramson Family Cancer Research Institute, University of Pennsylvania
    Howard Hughes Medical Institute
    University of Pennsylvania)

Abstract

Fructose-1,6-bisphosphatase is shown to be depleted in clear cell renal cell carcinoma (ccRCC) and inhibits ccRCC progression by antagonizing glycolytic flux in renal tubular epithelial cells and by restraining cell proliferation, glycolysis, and the pentose phosphate pathway in von Hippel–Lindau-protein-deficient ccRCC cells by blocking hypoxia-inducible factor function.

Suggested Citation

  • Bo Li & Bo Qiu & David S. M. Lee & Zandra E. Walton & Joshua D. Ochocki & Lijoy K. Mathew & Anthony Mancuso & Terence P. F. Gade & Brian Keith & Itzhak Nissim & M. Celeste Simon, 2014. "Fructose-1,6-bisphosphatase opposes renal carcinoma progression," Nature, Nature, vol. 513(7517), pages 251-255, September.
    • Handle: RePEc:nat:nature:v:513:y:2014:i:7517:d:10.1038_nature13557
    DOI: 10.1038/nature13557
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    Cited by:

    1. Marco Sciacovelli & Aurelien Dugourd & Lorea Valcarcel Jimenez & Ming Yang & Efterpi Nikitopoulou & Ana S. H. Costa & Laura Tronci & Veronica Caraffini & Paulo Rodrigues & Christina Schmidt & Dylan Ge, 2022. "Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

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