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Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

Author

Listed:
  • Hao Xu

    (National Institute of Biological Sciences)

  • Jieling Yang

    (National Institute of Biological Sciences
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences)

  • Wenqing Gao

    (National Institute of Biological Sciences)

  • Lin Li

    (National Institute of Biological Sciences)

  • Peng Li

    (National Institute of Biological Sciences)

  • Li Zhang

    (National Institute of Biological Sciences)

  • Yi-Nan Gong

    (National Institute of Biological Sciences)

  • Xiaolan Peng

    (National Institute of Biological Sciences)

  • Jianzhong Jeff Xi

    (College of Engineering, Peking University)

  • She Chen

    (National Institute of Biological Sciences)

  • Fengchao Wang

    (National Institute of Biological Sciences)

  • Feng Shao

    (National Institute of Biological Sciences
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
    National Institute of Biological Sciences, Beijing, Collaborative Innovation Center for Cancer Medicine)

Abstract

The Pyrin inflammasome detects the presence of a pathogen not through recognition of a microbial molecule but by the activity of a bacterial toxin that modifies host Rho activity.

Suggested Citation

  • Hao Xu & Jieling Yang & Wenqing Gao & Lin Li & Peng Li & Li Zhang & Yi-Nan Gong & Xiaolan Peng & Jianzhong Jeff Xi & She Chen & Fengchao Wang & Feng Shao, 2014. "Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome," Nature, Nature, vol. 513(7517), pages 237-241, September.
    • Handle: RePEc:nat:nature:v:513:y:2014:i:7517:d:10.1038_nature13449
    DOI: 10.1038/nature13449
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