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RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

Author

Listed:
  • Nozomi Takahashi

    (VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium
    Ghent University, Technologiepark 927, B-9052 Ghent, Belgium)

  • Lars Vereecke

    (VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium
    Ghent University, Technologiepark 927, B-9052 Ghent, Belgium)

  • Mathieu J. M. Bertrand

    (VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium
    Ghent University, Technologiepark 927, B-9052 Ghent, Belgium)

  • Linde Duprez

    (VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium
    Ghent University, Technologiepark 927, B-9052 Ghent, Belgium)

  • Scott B. Berger

    (Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline)

  • Tatyana Divert

    (VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium
    Ghent University, Technologiepark 927, B-9052 Ghent, Belgium)

  • Amanda Gonçalves

    (VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium
    Ghent University, Technologiepark 927, B-9052 Ghent, Belgium
    VIB Bio Imaging Core Gent, Technologiepark 927, B-9052 Ghent, Belgium)

  • Mozes Sze

    (VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium
    Ghent University, Technologiepark 927, B-9052 Ghent, Belgium)

  • Barbara Gilbert

    (VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium
    Ghent University, Technologiepark 927, B-9052 Ghent, Belgium)

  • Stephanie Kourula

    (VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium
    Ghent University, Technologiepark 927, B-9052 Ghent, Belgium)

  • Vera Goossens

    (VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium
    Ghent University, Technologiepark 927, B-9052 Ghent, Belgium)

  • Sylvie Lefebvre

    (VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium
    Ghent University, Technologiepark 927, B-9052 Ghent, Belgium)

  • Claudia Günther

    (Friedrich-Alexander-University, D-91054 Erlangen, Germany)

  • Christoph Becker

    (Friedrich-Alexander-University, D-91054 Erlangen, Germany)

  • John Bertin

    (Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline)

  • Peter J. Gough

    (Pattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline)

  • Wim Declercq

    (VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium
    Ghent University, Technologiepark 927, B-9052 Ghent, Belgium)

  • Geert van Loo

    (VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium
    Ghent University, Technologiepark 927, B-9052 Ghent, Belgium)

  • Peter Vandenabeele

    (VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium
    Ghent University, Technologiepark 927, B-9052 Ghent, Belgium
    Methusalem program, Ghent University, Technologiepark 927, B-9052 Ghent, Belgium)

Abstract

This study provides evidence for a critical role of RIPK1 in suppressing caspase-8-mediated cell death and maintaining intestinal homeostasis independently of its kinase activity.

Suggested Citation

  • Nozomi Takahashi & Lars Vereecke & Mathieu J. M. Bertrand & Linde Duprez & Scott B. Berger & Tatyana Divert & Amanda Gonçalves & Mozes Sze & Barbara Gilbert & Stephanie Kourula & Vera Goossens & Sylvi, 2014. "RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis," Nature, Nature, vol. 513(7516), pages 95-99, September.
    • Handle: RePEc:nat:nature:v:513:y:2014:i:7516:d:10.1038_nature13706
    DOI: 10.1038/nature13706
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    Cited by:

    1. Xinyu Mei & Yuan Guo & Zhangdan Xie & Yedan Zhong & Xiaofen Wu & Daichao Xu & Ying Li & Nan Liu & Zheng-Jiang Zhu, 2021. "RIPK1 regulates starvation resistance by modulating aspartate catabolism," Nature Communications, Nature, vol. 12(1), pages 1-16, December.

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