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eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies

Author

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  • Lise Boussemart

    (Inserm UMR981, Villejuif F-94805, France
    Université Paris-Sud XI, Kremlin-Bicêtre F-94276, France
    Gustave Roussy, Dermato-Oncology, Villejuif F-94805, France)

  • Hélène Malka-Mahieu

    (Inserm UMR981, Villejuif F-94805, France
    Université Paris-Sud XI, Kremlin-Bicêtre F-94276, France)

  • Isabelle Girault

    (Inserm UMR981, Villejuif F-94805, France)

  • Delphine Allard

    (Inserm UMR981, Villejuif F-94805, France)

  • Oskar Hemmingsson

    (Inserm UMR981, Villejuif F-94805, France
    Present addresses: Department of Surgical and Perioperative Sciences, Umeå University, Umeå SE-90187, Sweden (O.H.); CNRS UMR3348, Institut Curie, Orsay F-91405, France (S.V.).)

  • Gorana Tomasic

    (Gustave Roussy, Villejuif F-94805, France)

  • Marina Thomas

    (Gustave Roussy, Dermato-Oncology, Villejuif F-94805, France)

  • Christine Basmadjian

    (CNRS-Strasbourg University, UMR7200, Illkirch F-67400, France)

  • Nigel Ribeiro

    (CNRS-Strasbourg University, UMR7200, Illkirch F-67400, France)

  • Frédéric Thuaud

    (CNRS-Strasbourg University, UMR7200, Illkirch F-67400, France)

  • Christina Mateus

    (Gustave Roussy, Dermato-Oncology, Villejuif F-94805, France)

  • Emilie Routier

    (Gustave Roussy, Dermato-Oncology, Villejuif F-94805, France)

  • Nyam Kamsu-Kom

    (Inserm UMR981, Villejuif F-94805, France)

  • Sandrine Agoussi

    (Inserm UMR981, Villejuif F-94805, France)

  • Alexander M. Eggermont

    (Université Paris-Sud XI, Kremlin-Bicêtre F-94276, France
    Gustave Roussy, Dermato-Oncology, Villejuif F-94805, France)

  • Laurent Désaubry

    (CNRS-Strasbourg University, UMR7200, Illkirch F-67400, France)

  • Caroline Robert

    (Inserm UMR981, Villejuif F-94805, France
    Université Paris-Sud XI, Kremlin-Bicêtre F-94276, France
    Gustave Roussy, Dermato-Oncology, Villejuif F-94805, France)

  • Stéphan Vagner

    (Inserm UMR981, Villejuif F-94805, France
    Université Paris-Sud XI, Kremlin-Bicêtre F-94276, France
    Gustave Roussy, Dermato-Oncology, Villejuif F-94805, France
    Present addresses: Department of Surgical and Perioperative Sciences, Umeå University, Umeå SE-90187, Sweden (O.H.); CNRS UMR3348, Institut Curie, Orsay F-91405, France (S.V.).)

Abstract

BRAF mutations occur frequently in melanomas, but patients generally develop resistance to agents targeting mutant BRAF; now, the persistent formation of the translation initiation complex eIF4F has been described as an indicator of multiple mechanisms of resistance that arise in BRAF-mutated tumours and as a promising therapeutic target.

Suggested Citation

  • Lise Boussemart & Hélène Malka-Mahieu & Isabelle Girault & Delphine Allard & Oskar Hemmingsson & Gorana Tomasic & Marina Thomas & Christine Basmadjian & Nigel Ribeiro & Frédéric Thuaud & Christina Mat, 2014. "eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies," Nature, Nature, vol. 513(7516), pages 105-109, September.
    • Handle: RePEc:nat:nature:v:513:y:2014:i:7516:d:10.1038_nature13572
    DOI: 10.1038/nature13572
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    Cited by:

    1. Lorey K. Smith & Tiffany Parmenter & Margarete Kleinschmidt & Eric P. Kusnadi & Jian Kang & Claire A. Martin & Peter Lau & Riyaben Patel & Julie Lorent & David Papadopoli & Anna Trigos & Teresa Ward &, 2022. "Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAFV600 melanoma," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    2. Yuri Frosi & Yen-Chu Lin & Jiang Shimin & Siti Radhiah Ramlan & Kelly Hew & Alf Henrik Engman & Anil Pillai & Kit Yeung & Yue Xiang Cheng & Tobias Cornvik & Par Nordlund & Megan Goh & Dilraj Lama & Za, 2022. "Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    3. Hironori Saito & Yuma Handa & Mingming Chen & Tilman Schneider-Poetsch & Yuichi Shichino & Mari Takahashi & Daniel Romo & Minoru Yoshida & Alois Fürstner & Takuhiro Ito & Kaori Fukuzawa & Shintaro Iwa, 2024. "DMDA-PatA mediates RNA sequence-selective translation repression by anchoring eIF4A and DDX3 to GNG motifs," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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