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Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia

Author

Listed:
  • Serkan Kir

    (Dana-Farber Cancer Institute, Harvard Medical School)

  • James P. White

    (Dana-Farber Cancer Institute, Harvard Medical School)

  • Sandra Kleiner

    (Dana-Farber Cancer Institute, Harvard Medical School)

  • Lawrence Kazak

    (Dana-Farber Cancer Institute, Harvard Medical School)

  • Paul Cohen

    (Dana-Farber Cancer Institute, Harvard Medical School)

  • Vickie E. Baracos

    (University of Alberta, Edmonton T6G 1Z2, Canada)

  • Bruce M. Spiegelman

    (Dana-Farber Cancer Institute, Harvard Medical School)

Abstract

Many patients with cancer experience cachexia, a wasting disorder of adipose tissue and skeletal muscle that leads to weight loss and frailty; now, tumour-derived parathyroid-hormone-related protein has been shown to stimulate the expression of genes involved in heat production in adipose tissues and to have an important role in tissue wasting.

Suggested Citation

  • Serkan Kir & James P. White & Sandra Kleiner & Lawrence Kazak & Paul Cohen & Vickie E. Baracos & Bruce M. Spiegelman, 2014. "Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia," Nature, Nature, vol. 513(7516), pages 100-104, September.
    • Handle: RePEc:nat:nature:v:513:y:2014:i:7516:d:10.1038_nature13528
    DOI: 10.1038/nature13528
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    Cited by:

    1. Flavia A. Graca & Mamta Rai & Liam C. Hunt & Anna Stephan & Yong-Dong Wang & Brittney Gordon & Ruishan Wang & Giovanni Quarato & Beisi Xu & Yiping Fan & Myriam Labelle & Fabio Demontis, 2022. "The myokine Fibcd1 is an endogenous determinant of myofiber size and mitigates cancer-induced myofiber atrophy," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    2. Ertunc Erdil & Anton S. Becker & Moritz Schwyzer & Borja Martinez-Tellez & Jonatan R. Ruiz & Thomas Sartoretti & H. Alberto Vargas & A. Irene Burger & Alin Chirindel & Damian Wild & Nicola Zamboni & B, 2024. "Predicting standardized uptake value of brown adipose tissue from CT scans using convolutional neural networks," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    3. Shuai Yan & Anna Santoro & Micah J. Niphakis & Antonio M. Pinto & Christopher L. Jacobs & Rasheed Ahmad & Radu M. Suciu & Bryan R. Fonslow & Rachel A. Herbst-Graham & Nhi Ngo & Cassandra L. Henry & Dy, 2024. "Inflammation causes insulin resistance in mice via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    4. Andre Lima Queiroz & Ezequiel Dantas & Shakti Ramsamooj & Anirudh Murthy & Mujmmail Ahmed & Elizabeth R. M. Zunica & Roger J. Liang & Jessica Murphy & Corey D. Holman & Curtis J. Bare & Gregory Ghahra, 2022. "Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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