IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v513y2014i7516d10.1038_nature13494.html
   My bibliography  Save this article

High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875

Author

Listed:
  • Ankita Srivastava

    (Takeda California, 10410 Science Center Drive)

  • Jason Yano

    (Takeda California, 10410 Science Center Drive)

  • Yoshihiko Hirozane

    (Biomolecular Research Laboratories, Takeda Pharmaceutical Company Ltd, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan)

  • Georgia Kefala

    (Takeda California, 10410 Science Center Drive)

  • Franz Gruswitz

    (Takeda California, 10410 Science Center Drive
    Present addresses: Beryllium, Membrane Protein Sciences, 7869 NE Day Road West, Bainbridge Island, Washington 98110, USA (F.G.); Dart Neuroscience, 12278 Scripps Summit Drive, San Diego, California 92131, USA (K.A. and J.N.).)

  • Gyorgy Snell

    (Takeda California, 10410 Science Center Drive)

  • Weston Lane

    (Takeda California, 10410 Science Center Drive)

  • Anthony Ivetac

    (Takeda California, 10410 Science Center Drive)

  • Kathleen Aertgeerts

    (Takeda California, 10410 Science Center Drive
    Present addresses: Beryllium, Membrane Protein Sciences, 7869 NE Day Road West, Bainbridge Island, Washington 98110, USA (F.G.); Dart Neuroscience, 12278 Scripps Summit Drive, San Diego, California 92131, USA (K.A. and J.N.).)

  • Jasmine Nguyen

    (Takeda California, 10410 Science Center Drive
    Present addresses: Beryllium, Membrane Protein Sciences, 7869 NE Day Road West, Bainbridge Island, Washington 98110, USA (F.G.); Dart Neuroscience, 12278 Scripps Summit Drive, San Diego, California 92131, USA (K.A. and J.N.).)

  • Andy Jennings

    (Takeda California, 10410 Science Center Drive)

  • Kengo Okada

    (Biomolecular Research Laboratories, Takeda Pharmaceutical Company Ltd, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan)

Abstract

The X-ray crystal structure of human GPR40 receptor in the presence of TAK-875, an orally available, potent and selective human GPR40 agonist.

Suggested Citation

  • Ankita Srivastava & Jason Yano & Yoshihiko Hirozane & Georgia Kefala & Franz Gruswitz & Gyorgy Snell & Weston Lane & Anthony Ivetac & Kathleen Aertgeerts & Jasmine Nguyen & Andy Jennings & Kengo Okada, 2014. "High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875," Nature, Nature, vol. 513(7516), pages 124-127, September.
    • Handle: RePEc:nat:nature:v:513:y:2014:i:7516:d:10.1038_nature13494
    DOI: 10.1038/nature13494
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature13494
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature13494?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Xin Chen & Kexin Wang & Jianfang Chen & Chao Wu & Jun Mao & Yuanpeng Song & Yijing Liu & Zhenhua Shao & Xuemei Pu, 2024. "Integrative residue-intuitive machine learning and MD Approach to Unveil Allosteric Site and Mechanism for β2AR," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Joshua A. Lees & João M. Dias & Francis Rajamohan & Jean-Philippe Fortin & Rebecca O’Connor & Jimmy X. Kong & Emily A. G. Hughes & Ethan L. Fisher & Jamison B. Tuttle & Gabrielle Lovett & Bethany L. K, 2023. "An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:513:y:2014:i:7516:d:10.1038_nature13494. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.