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The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase

Author

Listed:
  • Fei Wang

    (Harvard University, Northwest Labs, Cambridge, Massachusetts 02138, USA)

  • Charlene Chan

    (Harvard University, Northwest Labs, Cambridge, Massachusetts 02138, USA)

  • Nicholas R. Weir

    (Harvard University, Northwest Labs, Cambridge, Massachusetts 02138, USA)

  • Vladimir Denic

    (Harvard University, Northwest Labs, Cambridge, Massachusetts 02138, USA)

Abstract

The receptor for the cytoplasmic factor that targets tail-anchored proteins to the endoplasmic reticulum is an enzyme that enables a facilitated insertion path into the lipid bilayer.

Suggested Citation

  • Fei Wang & Charlene Chan & Nicholas R. Weir & Vladimir Denic, 2014. "The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase," Nature, Nature, vol. 512(7515), pages 441-444, August.
    • Handle: RePEc:nat:nature:v:512:y:2014:i:7515:d:10.1038_nature13471
    DOI: 10.1038/nature13471
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    Cited by:

    1. Melanie A. McDowell & Michael Heimes & Giray Enkavi & Ákos Farkas & Daniel Saar & Klemens Wild & Blanche Schwappach & Ilpo Vattulainen & Irmgard Sinning, 2023. "The GET insertase exhibits conformational plasticity and induces membrane thinning," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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