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Jam1a–Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling

Author

Listed:
  • Isao Kobayashi

    (University of California, San Diego, La Jolla, California 92093-0380, USA)

  • Jingjing Kobayashi-Sun

    (University of California, San Diego, La Jolla, California 92093-0380, USA)

  • Albert D. Kim

    (University of California, San Diego, La Jolla, California 92093-0380, USA)

  • Claire Pouget

    (University of California, San Diego, La Jolla, California 92093-0380, USA)

  • Naonobu Fujita

    (Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, California 92093-0380, USA)

  • Toshio Suda

    (The Sakaguchi Laboratory, School of Medicine, Keio University, Shinjukuku, Tokyo 160-8582, Japan)

  • David Traver

    (University of California, San Diego, La Jolla, California 92093-0380, USA
    Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, California 92093-0380, USA)

Abstract

Notch signalling has a key role in the generation of haematopoietic stem cells (HSCs) during vertebrate development; here two adhesion molecules, Jam1a and Jam2a, are shown to be essential for the contact between precursors of HSCs and the somite during embryonic migration, and the Jam1a–Jam2a interaction is shown to be needed to transmit the Notch signal and produce HSCs.

Suggested Citation

  • Isao Kobayashi & Jingjing Kobayashi-Sun & Albert D. Kim & Claire Pouget & Naonobu Fujita & Toshio Suda & David Traver, 2014. "Jam1a–Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling," Nature, Nature, vol. 512(7514), pages 319-323, August.
    • Handle: RePEc:nat:nature:v:512:y:2014:i:7514:d:10.1038_nature13623
    DOI: 10.1038/nature13623
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    Cited by:

    1. Emi Murayama & Catherine Vivier & Anne Schmidt & Philippe Herbomel, 2023. "Alcam-a and Pdgfr-α are essential for the development of sclerotome-derived stromal cells that support hematopoiesis," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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