IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v512y2014i7514d10.1038_nature13387.html
   My bibliography  Save this article

A vaccine targeting mutant IDH1 induces antitumour immunity

Author

Listed:
  • Theresa Schumacher

    (University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany
    German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Lukas Bunse

    (University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany
    German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Stefan Pusch

    (University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany
    German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Felix Sahm

    (University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany
    German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Benedikt Wiestler

    (University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany
    German Cancer Consortium (DKTK) Clinical Cooperation Unit Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Jasmin Quandt

    (German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Oliver Menn

    (University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany)

  • Matthias Osswald

    (University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany
    German Cancer Consortium (DKTK) Clinical Cooperation Unit Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Iris Oezen

    (University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany
    German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Martina Ott

    (University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany
    German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Melanie Keil

    (University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany
    German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Jörg Balß

    (German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
    German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Katharina Rauschenbach

    (University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany
    German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Agnieszka K. Grabowska

    (German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Isabel Vogler

    (Ribological GmbH, 55131 Mainz, Germany)

  • Jan Diekmann

    (Translational Oncology, 55131 Mainz, Germany)

  • Nico Trautwein

    (University of Tübingen, 72076 Tübingen, Germany)

  • Stefan B. Eichmüller

    (German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Jürgen Okun

    (Metabolic Centre Heidelberg, University Children’s Hospital, 69120 Heidelberg, Germany)

  • Stefan Stevanović

    (University of Tübingen, 72076 Tübingen, Germany)

  • Angelika B. Riemer

    (German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Ugur Sahin

    (Translational Oncology, 55131 Mainz, Germany)

  • Manuel A. Friese

    (Center for Molecular Neurobiology, University Medical Center, Hamburg-Eppendorf, 20251 Hamburg, Germany)

  • Philipp Beckhove

    (German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Andreas von Deimling

    (University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany
    German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Wolfgang Wick

    (University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany
    German Cancer Consortium (DKTK) Clinical Cooperation Unit Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Michael Platten

    (University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany
    German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

Abstract

The mutant IDH1 protein, which is expressed in a large fraction of human gliomas, is shown to be immunogenic; mutant-specific immune responses can be detected in patients with IDH1 mutated gliomas and generated in mice and are shown to treat established IDH1 mutant tumours in a syngeneic MHC humanized mouse model in a CD4 T-cell-dependent manner.

Suggested Citation

  • Theresa Schumacher & Lukas Bunse & Stefan Pusch & Felix Sahm & Benedikt Wiestler & Jasmin Quandt & Oliver Menn & Matthias Osswald & Iris Oezen & Martina Ott & Melanie Keil & Jörg Balß & Katharina Raus, 2014. "A vaccine targeting mutant IDH1 induces antitumour immunity," Nature, Nature, vol. 512(7514), pages 324-327, August.
    • Handle: RePEc:nat:nature:v:512:y:2014:i:7514:d:10.1038_nature13387
    DOI: 10.1038/nature13387
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature13387
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature13387?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:512:y:2014:i:7514:d:10.1038_nature13387. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.