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A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

Author

Listed:
  • Ida Moltke

    (The Bioinformatics Centre, University of Copenhagen, 2200 Copenhagen, Denmark
    University of Chicago)

  • Niels Grarup

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark)

  • Marit E. Jørgensen

    (Steno Diabetes Center, 2820 Gentofte, Denmark)

  • Peter Bjerregaard

    (National Institute of Public Health, University of Southern Denmark, 1353 Copenhagen, Denmark)

  • Jonas T. Treebak

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Integrative Physiology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark)

  • Matteo Fumagalli

    (University of California)

  • Thorfinn S. Korneliussen

    (Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350 Copenhagen, Denmark)

  • Marianne A. Andersen

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Integrative Physiology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark)

  • Thomas S. Nielsen

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Integrative Physiology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark)

  • Nikolaj T. Krarup

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark)

  • Anette P. Gjesing

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark)

  • Juleen R. Zierath

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Integrative Physiology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark
    Karolinska Institute, 171 77 Stockholm, Sweden)

  • Allan Linneberg

    (Research Centre for Prevention and Health, Glostrup University Hospital, 2600 Glostrup, Denmark)

  • Xueli Wu

    (BGI-Shenzhen)

  • Guangqing Sun

    (BGI-Shenzhen)

  • Xin Jin

    (BGI-Shenzhen)

  • Jumana Al-Aama

    (BGI-Shenzhen
    Faculty of Medicine and Princess Al Jawhara Albrahim Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University, Jeddah 21589, Saudi Arabia)

  • Jun Wang

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark
    BGI-Shenzhen
    Faculty of Medicine and Princess Al Jawhara Albrahim Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University, Jeddah 21589, Saudi Arabia
    University of Copenhagen, 2200 Copenhagen, Denmark)

  • Knut Borch-Johnsen

    (Holbaek Hospital, 4300 Holbaek, Denmark)

  • Oluf Pedersen

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark)

  • Rasmus Nielsen

    (University of California
    University of California)

  • Anders Albrechtsen

    (The Bioinformatics Centre, University of Copenhagen, 2200 Copenhagen, Denmark)

  • Torben Hansen

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark
    Faculty of Health Sciences, University of Southern Denmark, 5000 Odense, Denmark)

Abstract

An association mapping study of type-2-diabetes-related quantitative traits in the Greenlandic population identified a common variant in TBC1D4 that increases plasma glucose levels and serum insulin levels after an oral glucose load and type 2 diabetes risk, with effect sizes several times larger than any previous findings of large-scale genome-wide association studies for these traits.

Suggested Citation

  • Ida Moltke & Niels Grarup & Marit E. Jørgensen & Peter Bjerregaard & Jonas T. Treebak & Matteo Fumagalli & Thorfinn S. Korneliussen & Marianne A. Andersen & Thomas S. Nielsen & Nikolaj T. Krarup & Ane, 2014. "A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes," Nature, Nature, vol. 512(7513), pages 190-193, August.
    • Handle: RePEc:nat:nature:v:512:y:2014:i:7513:d:10.1038_nature13425
    DOI: 10.1038/nature13425
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    Cited by:

    1. Mette K Andersen & Emil Jørsboe & Line Skotte & Kristian Hanghøj & Camilla H Sandholt & Ida Moltke & Niels Grarup & Timo Kern & Yuvaraj Mahendran & Bolette Søborg & Peter Bjerregaard & Christina V L L, 2020. "The derived allele of a novel intergenic variant at chromosome 11 associates with lower body mass index and a favorable metabolic phenotype in Greenlanders," PLOS Genetics, Public Library of Science, vol. 16(1), pages 1-17, January.
    2. E. Havula & S. Ghazanfar & N. Lamichane & D. Francis & K. Hasygar & Y. Liu & L. A. Alton & J. Johnstone & E. J. Needham & T. Pulpitel & T. Clark & H. N. Niranjan & V. Shang & V. Tong & N. Jiwnani & G., 2022. "Genetic variation of macronutrient tolerance in Drosophila melanogaster," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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