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DENR–MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth

Author

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  • Sibylle Schleich

    (German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
    Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), Falkenried 94, 20251 Hamburg, Germany)

  • Katrin Strassburger

    (German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Philipp Christoph Janiesch

    (Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), Falkenried 94, 20251 Hamburg, Germany)

  • Tatyana Koledachkina

    (Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), Falkenried 94, 20251 Hamburg, Germany)

  • Katharine K. Miller

    (Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), Falkenried 94, 20251 Hamburg, Germany)

  • Katharina Haneke

    (German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
    Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany)

  • Yong-Sheng Cheng

    (German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

  • Katrin Küchler

    (Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), Falkenried 94, 20251 Hamburg, Germany)

  • Georg Stoecklin

    (German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
    Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany)

  • Kent E. Duncan

    (Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), Falkenried 94, 20251 Hamburg, Germany)

  • Aurelio A. Teleman

    (German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany)

Abstract

This study identifies the DENR–MCT-1 complex as the first factors in animals specific for translation re-initiation downstream of upstream Open Reading Frames (uORFs).

Suggested Citation

  • Sibylle Schleich & Katrin Strassburger & Philipp Christoph Janiesch & Tatyana Koledachkina & Katharine K. Miller & Katharina Haneke & Yong-Sheng Cheng & Katrin Küchler & Georg Stoecklin & Kent E. Dunc, 2014. "DENR–MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth," Nature, Nature, vol. 512(7513), pages 208-212, August.
    • Handle: RePEc:nat:nature:v:512:y:2014:i:7513:d:10.1038_nature13401
    DOI: 10.1038/nature13401
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    Citations

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    Cited by:

    1. Omar M. Hedaya & Kadiam C. Venkata Subbaiah & Feng Jiang & Li Huitong Xie & Jiangbin Wu & Eng-Soon Khor & Mingyi Zhu & David H. Mathews & Chris Proschel & Peng Yao, 2023. "Secondary structures that regulate mRNA translation provide insights for ASO-mediated modulation of cardiac hypertrophy," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Katrin Strassburger & Marilena Lutz & Sandra Müller & Aurelio A. Teleman, 2021. "Ecdysone regulates Drosophila wing disc size via a TORC1 dependent mechanism," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    3. Ramona Weber & Leon Kleemann & Insa Hirschberg & Min-Yi Chung & Eugene Valkov & Cátia Igreja, 2022. "DAP5 enables main ORF translation on mRNAs with structured and uORF-containing 5′ leaders," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    4. Katharina Clemm von Hohenberg & Sandra Müller & Sibylle Schleich & Matthias Meister & Jonathan Bohlen & Thomas G. Hofmann & Aurelio A. Teleman, 2022. "Cyclin B/CDK1 and Cyclin A/CDK2 phosphorylate DENR to promote mitotic protein translation and faithful cell division," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    5. Baiwen Chen & Jiajia Hu & Xianting Hu & Huifang Chen & Rujuan Bao & Yatao Zhou & Youqiong Ye & Meixiao Zhan & Wei Cai & Huabin Li & Hua-Bing Li, 2022. "DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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