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Putative cis-regulatory drivers in colorectal cancer

Author

Listed:
  • Halit Ongen

    (University of Geneva Medical School, 1211 Geneva, Switzerland
    Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, 1211 Geneva, Switzerland
    Swiss Institute of Bioinformatics, 1211 Geneva, Switzerland)

  • Claus L. Andersen

    (Aarhus University Hospital, 8000 Aarhus, Denmark)

  • Jesper B. Bramsen

    (Aarhus University Hospital, 8000 Aarhus, Denmark)

  • Bodil Oster

    (Aarhus University Hospital, 8000 Aarhus, Denmark)

  • Mads H. Rasmussen

    (Aarhus University Hospital, 8000 Aarhus, Denmark)

  • Pedro G. Ferreira

    (University of Geneva Medical School, 1211 Geneva, Switzerland
    Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, 1211 Geneva, Switzerland
    Swiss Institute of Bioinformatics, 1211 Geneva, Switzerland)

  • Juan Sandoval

    (Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL))

  • Enrique Vidal

    (Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL))

  • Nicola Whiffin

    (The Institute of Cancer Research)

  • Alexandra Planchon

    (University of Geneva Medical School, 1211 Geneva, Switzerland
    Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, 1211 Geneva, Switzerland
    Swiss Institute of Bioinformatics, 1211 Geneva, Switzerland)

  • Ismael Padioleau

    (University of Geneva Medical School, 1211 Geneva, Switzerland
    Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, 1211 Geneva, Switzerland
    Swiss Institute of Bioinformatics, 1211 Geneva, Switzerland)

  • Deborah Bielser

    (University of Geneva Medical School, 1211 Geneva, Switzerland
    Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, 1211 Geneva, Switzerland
    Swiss Institute of Bioinformatics, 1211 Geneva, Switzerland)

  • Luciana Romano

    (University of Geneva Medical School, 1211 Geneva, Switzerland
    Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, 1211 Geneva, Switzerland
    Swiss Institute of Bioinformatics, 1211 Geneva, Switzerland)

  • Ian Tomlinson

    (Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK)

  • Richard S. Houlston

    (The Institute of Cancer Research)

  • Manel Esteller

    (Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL)
    School of Medicine, University of Barcelona, 08007 Barcelona, Barcelona, Spain
    Institució Catalana de Recerca i Estudis Avançats (ICREA))

  • Torben F. Orntoft

    (Aarhus University Hospital, 8000 Aarhus, Denmark)

  • Emmanouil T. Dermitzakis

    (University of Geneva Medical School, 1211 Geneva, Switzerland
    Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, 1211 Geneva, Switzerland
    Swiss Institute of Bioinformatics, 1211 Geneva, Switzerland)

Abstract

Examination of allele-specific expression identifies 71 genes with excess somatic cis-regulatory effects in colorectal cancer (CRC), and 1,693 and 948 expression quantitative trait loci (eQTLs) in normal samples and tumours, respectively (with 36% of tumour eQTLs exclusive to CRC); tumour-specific eQTLs are more enriched for low CRC genome-wide association study P values and accumulate more somatic mutations than shared eQTLs, suggesting a role as germline-derived cancer regulatory drivers.

Suggested Citation

  • Halit Ongen & Claus L. Andersen & Jesper B. Bramsen & Bodil Oster & Mads H. Rasmussen & Pedro G. Ferreira & Juan Sandoval & Enrique Vidal & Nicola Whiffin & Alexandra Planchon & Ismael Padioleau & Deb, 2014. "Putative cis-regulatory drivers in colorectal cancer," Nature, Nature, vol. 512(7512), pages 87-90, August.
    • Handle: RePEc:nat:nature:v:512:y:2014:i:7512:d:10.1038_nature13602
    DOI: 10.1038/nature13602
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    Cited by:

    1. Nikolaos M. R. Lykoskoufis & Evarist Planet & Halit Ongen & Didier Trono & Emmanouil T. Dermitzakis, 2024. "Transposable elements mediate genetic effects altering the expression of nearby genes in colorectal cancer," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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