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Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys

Author

Listed:
  • James B. Whitney

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
    Ragon Institute of MGH, MIT and Harvard)

  • Alison L. Hill

    (Program for Evolutionary Dynamics, Harvard University)

  • Srisowmya Sanisetty

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Pablo Penaloza-MacMaster

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Jinyan Liu

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Mayuri Shetty

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Lily Parenteau

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Crystal Cabral

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Jennifer Shields

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Stephen Blackmore

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Jeffrey Y. Smith

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Amanda L. Brinkman

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Lauren E. Peter

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Sheeba I. Mathew

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Kaitlin M. Smith

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Erica N. Borducchi

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Daniel I. S. Rosenbloom

    (Program for Evolutionary Dynamics, Harvard University)

  • Mark G. Lewis

    (Bioqual)

  • Jillian Hattersley

    (Gilead Sciences)

  • Bei Li

    (Gilead Sciences)

  • Joseph Hesselgesser

    (Gilead Sciences)

  • Romas Geleziunas

    (Gilead Sciences)

  • Merlin L. Robb

    (US Military HIV Research Program, Walter Reed Army Institute of Research)

  • Jerome H. Kim

    (US Military HIV Research Program, Walter Reed Army Institute of Research)

  • Nelson L. Michael

    (US Military HIV Research Program, Walter Reed Army Institute of Research)

  • Dan H. Barouch

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
    Ragon Institute of MGH, MIT and Harvard)

Abstract

Reservoirs of virus infection represent the most important reason why HIV-1 cannot be cured with current antiretroviral drugs; now the refractory viral reservoir is shown to be seeded as early as 3 days after infection in a monkey model, even before the virus is detected in the blood.

Suggested Citation

  • James B. Whitney & Alison L. Hill & Srisowmya Sanisetty & Pablo Penaloza-MacMaster & Jinyan Liu & Mayuri Shetty & Lily Parenteau & Crystal Cabral & Jennifer Shields & Stephen Blackmore & Jeffrey Y. Sm, 2014. "Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys," Nature, Nature, vol. 512(7512), pages 74-77, August.
    • Handle: RePEc:nat:nature:v:512:y:2014:i:7512:d:10.1038_nature13594
    DOI: 10.1038/nature13594
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    Cited by:

    1. Caroline Passaes & Delphine Desjardins & Anaïs Chapel & Valérie Monceaux & Julien Lemaitre & Adeline Mélard & Federico Perdomo-Celis & Cyril Planchais & Maël Gourvès & Nastasia Dimant & Annie David & , 2024. "Early antiretroviral therapy favors post-treatment SIV control associated with the expansion of enhanced memory CD8+ T-cells," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Xiaolei Wang & Eunice Vincent & Summer Siddiqui & Katherine Turnbull & Hong Lu & Robert Blair & Xueling Wu & Meagan Watkins & Widade Ziani & Jiasheng Shao & Lara A. Doyle-Meyers & Kasi E. Russell-Lodr, 2022. "Early treatment regimens achieve sustained virologic remission in infant macaques infected with SIV at birth," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Daniel B. Reeves & Bryan T. Mayer & Allan C. deCamp & Yunda Huang & Bo Zhang & Lindsay N. Carpp & Craig A. Magaret & Michal Juraska & Peter B. Gilbert & David C. Montefiori & Katharine J. Bar & E. Fab, 2023. "High monoclonal neutralization titers reduced breakthrough HIV-1 viral loads in the Antibody Mediated Prevention trials," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Victoria E. K. Walker-Sperling & Noe B. Mercado & Abishek Chandrashekar & Erica N. Borducchi & Jinyan Liu & Joseph P. Nkolola & Mark Lewis & Jeffrey P. Murry & Yunling Yang & Romas Geleziunas & Merlin, 2022. "Therapeutic efficacy of combined active and passive immunization in ART-suppressed, SHIV-infected rhesus macaques," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    5. Omolara O. Baiyegunhi & Jaclyn Mann & Trevor Khaba & Thandeka Nkosi & Anele Mbatha & Funsho Ogunshola & Caroline Chasara & Nasreen Ismail & Thandekile Ngubane & Ismail Jajbhay & Johan Pansegrouw & Kri, 2022. "CD8 lymphocytes mitigate HIV-1 persistence in lymph node follicular helper T cells during hyperacute-treated infection," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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