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Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms

Author

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  • Lorena Arranz

    (Stem Cell Niche Pathophysiology Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain)

  • Abel Sánchez-Aguilera

    (Stem Cell Niche Pathophysiology Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain)

  • Daniel Martín-Pérez

    (Stem Cell Niche Pathophysiology Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain)

  • Joan Isern

    (Stem Cell Niche Pathophysiology Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain)

  • Xavier Langa

    (Stem Cell Niche Pathophysiology Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain)

  • Alexandar Tzankov

    (University Hospital Basel, CH-4031 Basel, Switzerland)

  • Pontus Lundberg

    (University Hospital Basel, CH-4031 Basel, Switzerland)

  • Sandra Muntión

    (IBSAL-Hospital Universitario de Salamanca, 37007 Salamanca, Spain)

  • Yi-Shiuan Tzeng

    (National Taiwan University, Taipei 10002, Taiwan)

  • Dar-Ming Lai

    (National Taiwan University, Taipei 10002, Taiwan)

  • Jürg Schwaller

    (University Hospital Basel, CH-4031 Basel, Switzerland)

  • Radek C. Skoda

    (University Hospital Basel, CH-4031 Basel, Switzerland)

  • Simón Méndez-Ferrer

    (Stem Cell Niche Pathophysiology Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain)

Abstract

Myeloproliferative neoplasms are caused by mutations in the haematopoietic stem cell (HSC) compartment, and here the authors show that the HSC niche contributes to the pathogenesis; sympathetic innervation of mesenchymal stem cells (MSCs) is reduced in the bone marrow of patients, which leads to reduced MSC numbers and increased mutant HSC expansion, and restoring sympathetic regulation of MSCs with neuroprotective/sympathomimetic drugs prevents mutant HSC expansion.

Suggested Citation

  • Lorena Arranz & Abel Sánchez-Aguilera & Daniel Martín-Pérez & Joan Isern & Xavier Langa & Alexandar Tzankov & Pontus Lundberg & Sandra Muntión & Yi-Shiuan Tzeng & Dar-Ming Lai & Jürg Schwaller & Radek, 2014. "Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms," Nature, Nature, vol. 512(7512), pages 78-81, August.
    • Handle: RePEc:nat:nature:v:512:y:2014:i:7512:d:10.1038_nature13383
    DOI: 10.1038/nature13383
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    Citations

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    Cited by:

    1. Mohammed Ferdous-Ur Rahman & Yue Yang & Bao T. Le & Avik Dutta & Julia Posyniak & Patrick Faughnan & Mohammad A. Sayem & Nadine S. Aguilera & Golam Mohi, 2022. "Interleukin-1 contributes to clonal expansion and progression of bone marrow fibrosis in JAK2V617F-induced myeloproliferative neoplasm," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Shivam Rai & Elodie Grockowiak & Nils Hansen & Damien Luque Paz & Cedric B. Stoll & Hui Hao-Shen & Gabriele Mild-Schneider & Stefan Dirnhofer & Christopher J. Farady & Simón Méndez-Ferrer & Radek C. S, 2022. "Inhibition of interleukin-1β reduces myelofibrosis and osteosclerosis in mice with JAK2-V617F driven myeloproliferative neoplasm," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Alicia Villatoro & Vincent Cuminetti & Aurora Bernal & Carlos Torroja & Itziar Cossío & Alberto Benguría & Marc Ferré & Joanna Konieczny & Enrique Vázquez & Andrea Rubio & Peter Utnes & Almudena Tello, 2023. "Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation," Nature Communications, Nature, vol. 14(1), pages 1-28, December.
    4. Raymond K. H. Yip & Joel S. Rimes & Bianca D. Capaldo & François Vaillant & Kellie A. Mouchemore & Bhupinder Pal & Yunshun Chen & Elliot Surgenor & Andrew J. Murphy & Robin L. Anderson & Gordon K. Smy, 2021. "Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis," Nature Communications, Nature, vol. 12(1), pages 1-17, December.

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