IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v512y2014i7512d10.1038_nature13383.html
   My bibliography  Save this article

Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms

Author

Listed:
  • Lorena Arranz

    (Stem Cell Niche Pathophysiology Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain)

  • Abel Sánchez-Aguilera

    (Stem Cell Niche Pathophysiology Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain)

  • Daniel Martín-Pérez

    (Stem Cell Niche Pathophysiology Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain)

  • Joan Isern

    (Stem Cell Niche Pathophysiology Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain)

  • Xavier Langa

    (Stem Cell Niche Pathophysiology Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain)

  • Alexandar Tzankov

    (University Hospital Basel, CH-4031 Basel, Switzerland)

  • Pontus Lundberg

    (University Hospital Basel, CH-4031 Basel, Switzerland)

  • Sandra Muntión

    (IBSAL-Hospital Universitario de Salamanca, 37007 Salamanca, Spain)

  • Yi-Shiuan Tzeng

    (National Taiwan University, Taipei 10002, Taiwan)

  • Dar-Ming Lai

    (National Taiwan University, Taipei 10002, Taiwan)

  • Jürg Schwaller

    (University Hospital Basel, CH-4031 Basel, Switzerland)

  • Radek C. Skoda

    (University Hospital Basel, CH-4031 Basel, Switzerland)

  • Simón Méndez-Ferrer

    (Stem Cell Niche Pathophysiology Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain)

Abstract

Myeloproliferative neoplasms are caused by mutations in the haematopoietic stem cell (HSC) compartment, and here the authors show that the HSC niche contributes to the pathogenesis; sympathetic innervation of mesenchymal stem cells (MSCs) is reduced in the bone marrow of patients, which leads to reduced MSC numbers and increased mutant HSC expansion, and restoring sympathetic regulation of MSCs with neuroprotective/sympathomimetic drugs prevents mutant HSC expansion.

Suggested Citation

  • Lorena Arranz & Abel Sánchez-Aguilera & Daniel Martín-Pérez & Joan Isern & Xavier Langa & Alexandar Tzankov & Pontus Lundberg & Sandra Muntión & Yi-Shiuan Tzeng & Dar-Ming Lai & Jürg Schwaller & Radek, 2014. "Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms," Nature, Nature, vol. 512(7512), pages 78-81, August.
    • Handle: RePEc:nat:nature:v:512:y:2014:i:7512:d:10.1038_nature13383
    DOI: 10.1038/nature13383
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature13383
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature13383?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Mohammed Ferdous-Ur Rahman & Yue Yang & Bao T. Le & Avik Dutta & Julia Posyniak & Patrick Faughnan & Mohammad A. Sayem & Nadine S. Aguilera & Golam Mohi, 2022. "Interleukin-1 contributes to clonal expansion and progression of bone marrow fibrosis in JAK2V617F-induced myeloproliferative neoplasm," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Raymond K. H. Yip & Joel S. Rimes & Bianca D. Capaldo & François Vaillant & Kellie A. Mouchemore & Bhupinder Pal & Yunshun Chen & Elliot Surgenor & Andrew J. Murphy & Robin L. Anderson & Gordon K. Smy, 2021. "Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    3. Shivam Rai & Elodie Grockowiak & Nils Hansen & Damien Luque Paz & Cedric B. Stoll & Hui Hao-Shen & Gabriele Mild-Schneider & Stefan Dirnhofer & Christopher J. Farady & Simón Méndez-Ferrer & Radek C. S, 2022. "Inhibition of interleukin-1β reduces myelofibrosis and osteosclerosis in mice with JAK2-V617F driven myeloproliferative neoplasm," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Alicia Villatoro & Vincent Cuminetti & Aurora Bernal & Carlos Torroja & Itziar Cossío & Alberto Benguría & Marc Ferré & Joanna Konieczny & Enrique Vázquez & Andrea Rubio & Peter Utnes & Almudena Tello, 2023. "Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation," Nature Communications, Nature, vol. 14(1), pages 1-28, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:512:y:2014:i:7512:d:10.1038_nature13383. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.