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Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

Author

Listed:
  • Lieselotte Vande Walle

    (VIB, Ghent B-9000, Belgium
    Ghent University, Ghent B-9000, Belgium)

  • Nina Van Opdenbosch

    (VIB, Ghent B-9000, Belgium
    Ghent University, Ghent B-9000, Belgium)

  • Peggy Jacques

    (Ghent University, Ghent B-9000, Belgium)

  • Amelie Fossoul

    (VIB, Ghent B-9000, Belgium
    Ghent University, Ghent B-9000, Belgium)

  • Eveline Verheugen

    (Ghent University, Ghent B-9000, Belgium)

  • Peter Vogel

    (St. Jude Children’s Research Hospital)

  • Rudi Beyaert

    (Inflammation Research Center, VIB, Ghent B-9052, Belgium
    Ghent University, Ghent B-9052, Belgium)

  • Dirk Elewaut

    (Ghent University, Ghent B-9000, Belgium)

  • Thirumala-Devi Kanneganti

    (St. Jude Children’s Research Hospital)

  • Geert van Loo

    (Inflammation Research Center, VIB, Ghent B-9052, Belgium
    Ghent University, Ghent B-9052, Belgium)

  • Mohamed Lamkanfi

    (VIB, Ghent B-9000, Belgium
    Ghent University, Ghent B-9000, Belgium)

Abstract

Pathogenesis of rheumatoid arthritis depends critically on the NLRP3 inflammasome/interleukin-1 signalling axis.

Suggested Citation

  • Lieselotte Vande Walle & Nina Van Opdenbosch & Peggy Jacques & Amelie Fossoul & Eveline Verheugen & Peter Vogel & Rudi Beyaert & Dirk Elewaut & Thirumala-Devi Kanneganti & Geert van Loo & Mohamed Lamk, 2014. "Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis," Nature, Nature, vol. 512(7512), pages 69-73, August.
    • Handle: RePEc:nat:nature:v:512:y:2014:i:7512:d:10.1038_nature13322
    DOI: 10.1038/nature13322
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