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PVT1 dependence in cancer with MYC copy-number increase

Author

Listed:
  • Yuen-Yi Tseng

    (Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA)

  • Branden S. Moriarity

    (Masonic Cancer Center, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA)

  • Wuming Gong

    (Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA
    Masonic Cancer Center, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA)

  • Ryutaro Akiyama

    (Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA
    Stem Cell Institute, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA)

  • Ashutosh Tiwari

    (Masonic Cancer Center, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA
    Present address: Center for Bio-Design, Translational Health Science and Technology Institute, Gurgaon 122016, India.)

  • Hiroko Kawakami

    (Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA
    Stem Cell Institute, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA)

  • Peter Ronning

    (Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA)

  • Brian Reuland

    (Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA)

  • Kacey Guenther

    (Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA)

  • Thomas C. Beadnell

    (University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA)

  • Jaclyn Essig

    (Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA)

  • George M. Otto

    (Masonic Cancer Center, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA)

  • M. Gerard O’Sullivan

    (Masonic Cancer Center, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA)

  • David A. Largaespada

    (Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA
    Masonic Cancer Center, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA)

  • Kathryn L. Schwertfeger

    (Masonic Cancer Center, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA
    University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA)

  • York Marahrens

    (Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA)

  • Yasuhiko Kawakami

    (Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA
    Stem Cell Institute, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA)

  • Anindya Bagchi

    (Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA
    Masonic Cancer Center, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA)

Abstract

Pvt1 overexpression in mice contributes to high Myc levels due to 8q24.21 gain and to MYC-driven tumorigenesis.

Suggested Citation

  • Yuen-Yi Tseng & Branden S. Moriarity & Wuming Gong & Ryutaro Akiyama & Ashutosh Tiwari & Hiroko Kawakami & Peter Ronning & Brian Reuland & Kacey Guenther & Thomas C. Beadnell & Jaclyn Essig & George M, 2014. "PVT1 dependence in cancer with MYC copy-number increase," Nature, Nature, vol. 512(7512), pages 82-86, August.
    • Handle: RePEc:nat:nature:v:512:y:2014:i:7512:d:10.1038_nature13311
    DOI: 10.1038/nature13311
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    Cited by:

    1. Federica Conte & Giulia Fiscon & Matteo Chiara & Teresa Colombo & Lorenzo Farina & Paola Paci, 2017. "Role of the long non-coding RNA PVT1 in the dysregulation of the ceRNA-ceRNA network in human breast cancer," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-22, February.
    2. Weiwei Han & Zhenyu Zhang & Bangshun He & Yijun Xu & Jun Zhang & Weijun Cao, 2017. "Integrated analysis of long non-coding RNAs in human gastric cancer: An in silico study," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-12, August.
    3. F. Nadalin & M. J. Marzi & M. Pirra Piscazzi & P. Fuentes-Bravo & S. Procaccia & M. Climent & P. Bonetti & C. Rubolino & B. Giuliani & I. Papatheodorou & J. C. Marioni & F. Nicassio, 2024. "Multi-omic lineage tracing predicts the transcriptional, epigenetic and genetic determinants of cancer evolution," Nature Communications, Nature, vol. 15(1), pages 1-23, December.

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