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Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis

Author

Listed:
  • Arianna Sabò

    (Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), Via Adamello 16, 20139 Milan, Italy
    European Institute of Oncology (IEO), Via Adamello 16, 20139 Milan, Italy)

  • Theresia R. Kress

    (Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), Via Adamello 16, 20139 Milan, Italy
    European Institute of Oncology (IEO), Via Adamello 16, 20139 Milan, Italy)

  • Mattia Pelizzola

    (Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), Via Adamello 16, 20139 Milan, Italy)

  • Stefano de Pretis

    (Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), Via Adamello 16, 20139 Milan, Italy)

  • Marcin M. Gorski

    (European Institute of Oncology (IEO), Via Adamello 16, 20139 Milan, Italy)

  • Alessandra Tesi

    (Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), Via Adamello 16, 20139 Milan, Italy)

  • Marco J. Morelli

    (Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), Via Adamello 16, 20139 Milan, Italy)

  • Pranami Bora

    (Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), Via Adamello 16, 20139 Milan, Italy)

  • Mirko Doni

    (European Institute of Oncology (IEO), Via Adamello 16, 20139 Milan, Italy)

  • Alessandro Verrecchia

    (European Institute of Oncology (IEO), Via Adamello 16, 20139 Milan, Italy)

  • Claudia Tonelli

    (European Institute of Oncology (IEO), Via Adamello 16, 20139 Milan, Italy)

  • Giovanni Fagà

    (European Institute of Oncology (IEO), Via Adamello 16, 20139 Milan, Italy)

  • Valerio Bianchi

    (Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), Via Adamello 16, 20139 Milan, Italy)

  • Alberto Ronchi

    (Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), Via Adamello 16, 20139 Milan, Italy)

  • Diana Low

    (Institute of Molecular and Cell Biology, Singapore 138673, Singapore)

  • Heiko Müller

    (Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), Via Adamello 16, 20139 Milan, Italy)

  • Ernesto Guccione

    (Institute of Molecular and Cell Biology, Singapore 138673, Singapore)

  • Stefano Campaner

    (Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), Via Adamello 16, 20139 Milan, Italy)

  • Bruno Amati

    (Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), Via Adamello 16, 20139 Milan, Italy
    European Institute of Oncology (IEO), Via Adamello 16, 20139 Milan, Italy)

Abstract

Global transcriptional and epigenomic analyses in diverse cell types reveal that the primary action of Myc is to up- and downregulate transcription of distinct groups of genes, rather than to amplify transcription of all active genes; general RNA amplification, when observed, is better explained as an indirect consequence of Myc’s action on cellular physiology.

Suggested Citation

  • Arianna Sabò & Theresia R. Kress & Mattia Pelizzola & Stefano de Pretis & Marcin M. Gorski & Alessandra Tesi & Marco J. Morelli & Pranami Bora & Mirko Doni & Alessandro Verrecchia & Claudia Tonelli & , 2014. "Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis," Nature, Nature, vol. 511(7510), pages 488-492, July.
    • Handle: RePEc:nat:nature:v:511:y:2014:i:7510:d:10.1038_nature13537
    DOI: 10.1038/nature13537
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    Cited by:

    1. Laura Curti & Sara Rohban & Nicola Bianchi & Ottavio Croci & Adrian Andronache & Sara Barozzi & Michela Mattioli & Fernanda Ricci & Elena Pastori & Silvia Sberna & Simone Bellotti & Anna Accialini & R, 2024. "CDK12 controls transcription at damaged genes and prevents MYC-induced transcription-replication conflicts," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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