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Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles

Author

Listed:
  • Susanne Walz

    (Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany)

  • Francesca Lorenzin

    (Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany)

  • Jennifer Morton

    (CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK)

  • Katrin E. Wiese

    (Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany)

  • Björn von Eyss

    (Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany)

  • Steffi Herold

    (Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany)

  • Lukas Rycak

    (Institute for Molecular Biology and Tumor Research (IMT), Emil-Mannkopff-Str.2, 35033 Marburg, Germany)

  • Hélène Dumay-Odelot

    (University of Bordeaux, IECB, ARNA laboratory, Equipe Labellisée Contre le Cancer, 33600 Pessac, France)

  • Saadia Karim

    (CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK)

  • Marek Bartkuhn

    (Institute for Genetics, Justus-Liebig-University, Heinrich-Buff-Ring 58, 35390 Giessen, Germany)

  • Frederik Roels

    (University Children’s Hospital of Cologne, and Cologne Center for Molecular Medicine (CMMC), University of Cologne, Kerpener Str. 62, 50924 Cologne, Germany)

  • Torsten Wüstefeld

    (University Hospital Tübingen, Otfried-Mueller-Strasse 10, 72076 Tübingen, Germany)

  • Matthias Fischer

    (University Children’s Hospital of Cologne, and Cologne Center for Molecular Medicine (CMMC), University of Cologne, Kerpener Str. 62, 50924 Cologne, Germany)

  • Martin Teichmann

    (University of Bordeaux, IECB, ARNA laboratory, Equipe Labellisée Contre le Cancer, 33600 Pessac, France)

  • Lars Zender

    (University Hospital Tübingen, Otfried-Mueller-Strasse 10, 72076 Tübingen, Germany
    Translational Gastrointestinal Oncology Group within the German Center for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany)

  • Chia-Lin Wei

    (DOE Joint Genome Institute, 2800 Mitchell Drive)

  • Owen Sansom

    (CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK)

  • Elmar Wolf

    (Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany
    Rudolf Virchow Center/DFG Research Center for Experimental Biomedicine, University of Würzburg, Josef-Schneider-Str.2, 97080 Würzburg, Germany)

  • Martin Eilers

    (Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany
    Comprehensive Cancer Center Mainfranken, University of Würzburg, Josef-Schneider-Str. 6, 97080 Würzburg, Germany)

Abstract

Inducing changes in the levels of the MYC oncoprotein is shown to activate and repress specific sets of target genes that are characteristic of tumour cells, providing an insight into the mechanism by which MYC can stimulate tumorigenesis in contrast to its physiological role.

Suggested Citation

  • Susanne Walz & Francesca Lorenzin & Jennifer Morton & Katrin E. Wiese & Björn von Eyss & Steffi Herold & Lukas Rycak & Hélène Dumay-Odelot & Saadia Karim & Marek Bartkuhn & Frederik Roels & Torsten Wü, 2014. "Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles," Nature, Nature, vol. 511(7510), pages 483-487, July.
    • Handle: RePEc:nat:nature:v:511:y:2014:i:7510:d:10.1038_nature13473
    DOI: 10.1038/nature13473
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    Citations

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    Cited by:

    1. Nicole M. Sodir & Luca Pellegrinet & Roderik M. Kortlever & Tania Campos & Yong-Won Kwon & Shinseog Kim & Daniel Garcia & Alessandra Perfetto & Panayiotis Anastasiou & Lamorna Brown Swigart & Mark J. , 2022. "Reversible Myc hypomorphism identifies a key Myc-dependency in early cancer evolution," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Joy Edwards-Hicks & Huizhong Su & Maurizio Mangolini & Kubra K. Yoneten & Jimi Wills & Giovanny Rodriguez-Blanco & Christine Young & Kevin Cho & Heather Barker & Morwenna Muir & Ania Naila Guerrieri &, 2022. "MYC sensitises cells to apoptosis by driving energetic demand," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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