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Receptor binding by H10 influenza viruses

Author

Listed:
  • Sebastien G. Vachieri

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Xiaoli Xiong

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Patrick J. Collins

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Philip A. Walker

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Stephen R. Martin

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Lesley F. Haire

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Ying Zhang

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • John W. McCauley

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Steven J. Gamblin

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • John J. Skehel

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

Abstract

The structure and receptor-binding characteristics are presented of the haemagglutinin (HA) from an avian H10N2 virus that closely resembles an isolate from recent human fatalities; although avian H10 has a marked preference for the avian receptor, it is already able to bind to the human receptor, and its structure in complex with the human receptor shows similarities to HA from pandemic H1 and H7 viruses.

Suggested Citation

  • Sebastien G. Vachieri & Xiaoli Xiong & Patrick J. Collins & Philip A. Walker & Stephen R. Martin & Lesley F. Haire & Ying Zhang & John W. McCauley & Steven J. Gamblin & John J. Skehel, 2014. "Receptor binding by H10 influenza viruses," Nature, Nature, vol. 511(7510), pages 475-477, July.
    • Handle: RePEc:nat:nature:v:511:y:2014:i:7510:d:10.1038_nature13443
    DOI: 10.1038/nature13443
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