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C. elegans Punctin specifies cholinergic versus GABAergic identity of postsynaptic domains

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  • Bérangère Pinan-Lucarré

    (Institute of Biology, École Normale Supérieure, 75005 Paris, France
    University Claude Bernard Lyon 1, CGphiMC UMR CNRS 5534, 69622 Villeurbanne, France)

  • Haijun Tu

    (Institute of Biology, École Normale Supérieure, 75005 Paris, France
    University Claude Bernard Lyon 1, CGphiMC UMR CNRS 5534, 69622 Villeurbanne, France)

  • Marie Pierron

    (Institute of Biology, École Normale Supérieure, 75005 Paris, France
    University Claude Bernard Lyon 1, CGphiMC UMR CNRS 5534, 69622 Villeurbanne, France)

  • Pablo Ibáñez Cruceyra

    (Institute of Biology, École Normale Supérieure, 75005 Paris, France)

  • Hong Zhan

    (Institute of Biology, École Normale Supérieure, 75005 Paris, France
    University Claude Bernard Lyon 1, CGphiMC UMR CNRS 5534, 69622 Villeurbanne, France)

  • Christian Stigloher

    (Institute of Biology, École Normale Supérieure, 75005 Paris, France
    Present address: University of Würzburg, Biocenter, Division of Electron Microscopy, Am Hubland, 97074 Würzburg, Germany.)

  • Janet E. Richmond

    (University of Illinois at Chicago)

  • Jean-Louis Bessereau

    (Institute of Biology, École Normale Supérieure, 75005 Paris, France
    University Claude Bernard Lyon 1, CGphiMC UMR CNRS 5534, 69622 Villeurbanne, France)

Abstract

Two presynaptically secreted isoforms of the protein Punctin in the nematode Caenorhabditis elegans determine the postsynaptic accumulation of acetylcholine versus GABA receptors, raising the question of whether the related human punctin-2 gene, which has been associated with schizophrenia, may also control synaptic organization.

Suggested Citation

  • Bérangère Pinan-Lucarré & Haijun Tu & Marie Pierron & Pablo Ibáñez Cruceyra & Hong Zhan & Christian Stigloher & Janet E. Richmond & Jean-Louis Bessereau, 2014. "C. elegans Punctin specifies cholinergic versus GABAergic identity of postsynaptic domains," Nature, Nature, vol. 511(7510), pages 466-470, July.
    • Handle: RePEc:nat:nature:v:511:y:2014:i:7510:d:10.1038_nature13313
    DOI: 10.1038/nature13313
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