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WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis

Author

Listed:
  • Hong Ouyang

    (State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
    and Biomaterial and Tissue Engineering Center of Institute of Engineering in Medicine, University of California San Diego)

  • Yuanchao Xue

    (University of California San Diego)

  • Ying Lin

    (State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
    and Biomaterial and Tissue Engineering Center of Institute of Engineering in Medicine, University of California San Diego)

  • Xiaohui Zhang

    (and Biomaterial and Tissue Engineering Center of Institute of Engineering in Medicine, University of California San Diego
    Present addresses: Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing 100730, China (X.Z.); Department of Ophthalmology, Shengjing Hospital of China Medical University, Shenyang 110004, China (Y.Y.).)

  • Lei Xi

    (State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
    and Biomaterial and Tissue Engineering Center of Institute of Engineering in Medicine, University of California San Diego)

  • Sherrina Patel

    (and Biomaterial and Tissue Engineering Center of Institute of Engineering in Medicine, University of California San Diego)

  • Huimin Cai

    (Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan 610041, China
    Guangzhou KangRui Biological Pharmaceutical Technology Company Ltd.)

  • Jing Luo

    (and Biomaterial and Tissue Engineering Center of Institute of Engineering in Medicine, University of California San Diego)

  • Meixia Zhang

    (Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan 610041, China)

  • Ming Zhang

    (Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan 610041, China)

  • Yang Yang

    (and Biomaterial and Tissue Engineering Center of Institute of Engineering in Medicine, University of California San Diego
    Present addresses: Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing 100730, China (X.Z.); Department of Ophthalmology, Shengjing Hospital of China Medical University, Shenyang 110004, China (Y.Y.).)

  • Gen Li

    (Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan 610041, China)

  • Hairi Li

    (University of California San Diego)

  • Wei Jiang

    (Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan 610041, China)

  • Emily Yeh

    (and Biomaterial and Tissue Engineering Center of Institute of Engineering in Medicine, University of California San Diego)

  • Jonathan Lin

    (and Biomaterial and Tissue Engineering Center of Institute of Engineering in Medicine, University of California San Diego)

  • Michelle Pei

    (and Biomaterial and Tissue Engineering Center of Institute of Engineering in Medicine, University of California San Diego)

  • Jin Zhu

    (and Biomaterial and Tissue Engineering Center of Institute of Engineering in Medicine, University of California San Diego)

  • Guiqun Cao

    (Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan 610041, China)

  • Liangfang Zhang

    (and Biomaterial and Tissue Engineering Center of Institute of Engineering in Medicine, University of California San Diego
    University of California San Diego)

  • Benjamin Yu

    (University of California San Diego
    Institute for Genomic Medicine, University of California San Diego)

  • Shaochen Chen

    (and Biomaterial and Tissue Engineering Center of Institute of Engineering in Medicine, University of California San Diego
    University of California San Diego)

  • Xiang-Dong Fu

    (and Biomaterial and Tissue Engineering Center of Institute of Engineering in Medicine, University of California San Diego
    University of California San Diego
    Institute for Genomic Medicine, University of California San Diego)

  • Yizhi Liu

    (State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University)

  • Kang Zhang

    (State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
    and Biomaterial and Tissue Engineering Center of Institute of Engineering in Medicine, University of California San Diego
    Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan 610041, China
    Institute for Genomic Medicine, University of California San Diego)

Abstract

p63 and PAX6 act to specify limbal stem or progenitor cells (LSCs), and WNT7A controls corneal epithelium differentiation through PAX6; loss of WNT7A or PAX6 induces LSCs into epithelium, and transduction of PAX6 in skin epithelial stem cells converts them to LSC-like cells and transplantation in a rabbit corneal injury model can replenish corneal epithelial cells and repair damaged corneal surface.

Suggested Citation

  • Hong Ouyang & Yuanchao Xue & Ying Lin & Xiaohui Zhang & Lei Xi & Sherrina Patel & Huimin Cai & Jing Luo & Meixia Zhang & Ming Zhang & Yang Yang & Gen Li & Hairi Li & Wei Jiang & Emily Yeh & Jonathan L, 2014. "WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis," Nature, Nature, vol. 511(7509), pages 358-361, July.
    • Handle: RePEc:nat:nature:v:511:y:2014:i:7509:d:10.1038_nature13465
    DOI: 10.1038/nature13465
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