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ABCB5 is a limbal stem cell gene required for corneal development and repair

Author

Listed:
  • Bruce R. Ksander

    (Schepens Eye Research Institute, Massachusetts Eye & Ear Infirmary and Harvard Medical School)

  • Paraskevi E. Kolovou

    (Schepens Eye Research Institute, Massachusetts Eye & Ear Infirmary and Harvard Medical School)

  • Brian J. Wilson

    (Transplant Research Program, Boston Children’s Hospital
    Brigham and Women’s Hospital
    VA Boston Healthcare System)

  • Karim R. Saab

    (Transplant Research Program, Boston Children’s Hospital
    Brigham and Women’s Hospital)

  • Qin Guo

    (Transplant Research Program, Boston Children’s Hospital
    Brigham and Women’s Hospital
    VA Boston Healthcare System)

  • Jie Ma

    (Transplant Research Program, Boston Children’s Hospital
    Brigham and Women’s Hospital)

  • Sean P. McGuire

    (Schepens Eye Research Institute, Massachusetts Eye & Ear Infirmary and Harvard Medical School)

  • Meredith S. Gregory

    (Schepens Eye Research Institute, Massachusetts Eye & Ear Infirmary and Harvard Medical School)

  • William J. B. Vincent

    (Schepens Eye Research Institute, Massachusetts Eye & Ear Infirmary and Harvard Medical School)

  • Victor L. Perez

    (University of Miami Miller School of Medicine)

  • Fernando Cruz-Guilloty

    (University of Miami Miller School of Medicine)

  • Winston W. Y. Kao

    (University of Cincinnati Medical Center)

  • Mindy K. Call

    (University of Cincinnati Medical Center)

  • Budd A. Tucker

    (Stephen A Wynn Institute for Vision Research, Carver College of Medicine, University of Iowa)

  • Qian Zhan

    (Brigham and Women’s Hospital)

  • George F. Murphy

    (Brigham and Women’s Hospital)

  • Kira L. Lathrop

    (University of Pittsburgh Swanson School of Engineering)

  • Clemens Alt

    (Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School)

  • Luke J. Mortensen

    (Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School)

  • Charles P. Lin

    (Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School)

  • James D. Zieske

    (Schepens Eye Research Institute, Massachusetts Eye & Ear Infirmary and Harvard Medical School)

  • Markus H. Frank

    (Transplant Research Program, Boston Children’s Hospital
    Brigham and Women’s Hospital
    Harvard Stem Cell Institute, Harvard Medical School)

  • Natasha Y. Frank

    (Transplant Research Program, Boston Children’s Hospital
    VA Boston Healthcare System
    Harvard Stem Cell Institute, Harvard Medical School
    Brigham and Women’s Hospital)

Abstract

The loss of limbal stem cells (LSCs) due to injury or disease is one of the leading causes of blindness; here, the ABCB5 protein is identified as a marker of LSCs in mouse and human eye, and shown to be functionally required for LSC maintenance, corneal development and repair.

Suggested Citation

  • Bruce R. Ksander & Paraskevi E. Kolovou & Brian J. Wilson & Karim R. Saab & Qin Guo & Jie Ma & Sean P. McGuire & Meredith S. Gregory & William J. B. Vincent & Victor L. Perez & Fernando Cruz-Guilloty , 2014. "ABCB5 is a limbal stem cell gene required for corneal development and repair," Nature, Nature, vol. 511(7509), pages 353-357, July.
    • Handle: RePEc:nat:nature:v:511:y:2014:i:7509:d:10.1038_nature13426
    DOI: 10.1038/nature13426
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    Cited by:

    1. Mingsen Li & Huizhen Guo & Bofeng Wang & Zhuo Han & Siqi Wu & Jiafeng Liu & Huaxing Huang & Jin Zhu & Fengjiao An & Zesong Lin & Kunlun Mo & Jieying Tan & Chunqiao Liu & Li Wang & Xin Deng & Guigang L, 2024. "The single-cell transcriptomic atlas and RORA-mediated 3D epigenomic remodeling in driving corneal epithelial differentiation," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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